Zona Pellucida Glycoprotein 3 Antikörper (C-Term)

Produktnummer ABIN2776494

Produktdetails anti-Zona Pellucida Glycoprotein 3 Antikörper

Target: Zona Pellucida Glycoprotein 3 (ZP3)

Bindungsspezifität: C-Term

Reaktivität: Human, Ratte, Rind (Kuh), Pferd, Kaninchen

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Zona Pellucida Glycoprotein 3 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Sequenz: NKGDCGTPSH SRRQPHVMSQ WSRSASRNRR HVTEEADVTV GATDLPGQEW

Homologie: Cow: 100%, Horse: 100%, Human: 100%, Rabbit: 100%, Rat: 90%

Produktmerkmale: This is a rabbit polyclonal antibody against ZP3. It was validated on Western Blot using a cell lysate as a positive control.

Aufreinigung: Protein A purified

Immunogen: The immunogen is a synthetic peptide directed towards the C terminal region of human ZP3

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator.

Kommentare:

Antigen size: 424 AA

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Referenzen für anti-Zona Pellucida Glycoprotein 3 Antikörper (ABIN2776494)

Amorim, Moya, Donnez, Dolmans: "Morphometric characteristics of preantral and antral follicles and expression of factors involved in folliculogenesis in ovaries of adult baboons (Papio anubis)." in: Journal of assisted reproduction and genetics, Vol. 33, Issue 5, pp. 617-626, (2016) (PubMed).

Törmälä, Jääskeläinen, Lakkakorpi, Liakka, Tapanainen, Vaskivuo: "Zona pellucida components are present in human fetal ovary before follicle formation." in: Molecular and cellular endocrinology, Vol. 289, Issue 1-2, pp. 10-5, (2008) (PubMed).

Details zu Zona Pellucida Glycoprotein 3

Target: Zona Pellucida Glycoprotein 3 (ZP3)

Andere Bezeichnung: ZP3 (ZP3 Produkte)

Synonyme: ZP3A antikoerper, ZP3B antikoerper, ZPC antikoerper, Zp-3 antikoerper, zp3.2 antikoerper, Zp-3B antikoerper, zona pellucida glycoprotein 3 antikoerper, zona pellucida sperm-binding protein 3 antikoerper, ZP3 antikoerper, zp3 antikoerper, Zp3 antikoerper

Hintergrund: The zona pellucida is an extracellular matrix that surrounds the oocyte and early embryo. It is composed primarily of three or four glycoproteins with various functions during fertilization and preimplantation development. The protein encoded by this gene is a structural component of the zona pellucida and functions in primary binding and induction of the sperm acrosome reaction. The nascent protein contains a N-terminal signal peptide sequence, a conserved ZP domain, a C-terminal consensus furin cleavage site, and a transmembrane domain. It is hypothesized that furin cleavage results in release of the mature protein from the plasma membrane for subsequent incorporation into the zona pellucida matrix. However, the requirement for furin cleavage in this process remains controversial based on mouse studies. A variation in the last exon of this gene has previously served as the basis for an additional ZP3 locus, however, sequence and literature review reveals that there is only one full-length ZP3 locus in the human genome. Another locus encoding a bipartite transcript designated POMZP3 contains a duplication of the last four exons of ZP3, including the above described variation, and maps closely to this gene
Alias Symbols: ZPC, ZP3A, ZP3B, Zp-3
Protein Interaction Partner: HECW2, OR2L13, SPACA3, MICALL1, MRPS16, PCDH17, UBAP2L, UBC, ENGASE, ACR, FURIN,
Protein Size: 424

Molekulargewicht: 47 kDa

Gen-ID: 7784

Pathways: Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process