Histone Deacetylase 9 (HDAC9) (C-Term) Antikörper

Details zu Produkt Nr. ABIN2775576, Anbieter: Anmelden zum Anzeigen
Antigen
  • HD7
  • HD7b
  • HD9
  • HDAC
  • HDAC7
  • HDAC7B
  • HDAC9B
  • HDAC9FL
  • HDRP
  • MITR
  • AV022454
  • D030072B18Rik
  • HD7B
  • Hdac7b
  • Mitr
  • mKIAA0744
  • hdac9
  • zgc:73392
  • TWIST
  • HDAC9
  • DKFZp459E171
  • HDA09
  • HISTONE DEACETYLASE
  • histone deacetylase 9
  • RGD1310748
  • RGD1563092
  • hdac9-A
  • histone deacetylase 9
  • histone deacetylase 9b
  • histone deacetylase 9 S homeolog
  • HDAC9
  • Hdac9
  • hdac9b
  • HDA9
  • hdac9.S
Epitop
C-Term
23
14
14
14
12
6
5
4
3
3
2
2
2
2
2
2
1
1
1
Reaktivität
Meerschweinchen, Human, Maus, Schaf
129
26
22
8
5
3
3
3
2
2
2
2
1
1
1
1
Wirt
Kaninchen
105
24
Klonalität
Polyklonal
Konjugat
Unkonjugiert
4
4
4
4
4
4
Applikation
Chromatin Immunoprecipitation (ChIP), Immunohistochemistry (IHC), Western Blotting (WB)
119
62
53
40
39
24
13
5
2
2
1
Optionen
Hersteller
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Hersteller Produkt- Nr.
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Immunogen The immunogen is a synthetic peptide directed towards the C terminal region of human HDAC9
Sequenz QVGAVKVKEE PVDSDEDAQI QEMESGEQAA FMQQVIGKDL APGFVIKVII
Homologie Guinea Pig: 100%, Human: 100%, Mouse: 100%, Sheep: 100%
Produktmerkmale This is a rabbit polyclonal antibody against HDAC9. It was validated on Western Blot and immunohistochemistry.
Reinigung Protein A purified
Andere Bezeichnung HDAC9 (HDAC9 Antibody Abstract)
Hintergrund Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. HDAC9 has sequence homology to members of the histone deacetylase family. The MITR protein lacks the histone deacetylase catalytic domain. It represses MEF2 activity through recruitment of multicomponent corepressor complexes that include CtBP and HDACs. HDAC9 may play a role in hematopoiesis.Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene has sequence homology to members of the histone deacetylase family. This gene is orthologous to the Xenopus and mouse MITR genes. The MITR protein lacks the histone deacetylase catalytic domain. It represses MEF2 activity through recruitment of multicomponent corepressor complexes that include CtBP and HDACs. This encoded protein may play a role in hematopoiesis. Multiple alternatively spliced transcripts have been described for this gene but the full-length nature of some of them has not been determined.
Alias Symbols: DKFZp779K1053, HD7, HDAC, HDAC7, HDAC7B, HDAC9B, HDAC9FL, HDRP, KIAA0744, MITR, HD9, HD7b
Protein Interaction Partner: NOP2, MKI67, EIF6, RCC1, ADAR, TOP1, TMPO, FIP1L1, CCAR2, TPX2, RBM14, ZC3H11A, HDAC9, NUP93, SMC3, H1FX, TPR, HINT1, CTBP1, BCL6, Zfp521, TRIM29, TP53, MAML1, SMARCA4, PARP1, CEBPB, H3F3A, RL2, CAMK1, YWHAE, HDAC1, SFN, MEF2B, ANKRA2, RFXANK, PKD1, SYK,
Protein Size: 590
Molekulargewicht 65 kDa
Gen-ID 9734
NCBI Accession NM_014707, NP_055522
Forschungsgebiet Cardiovascular, Hypertrophy, DNA/RNA, Transcription Factors
Pathways Regulation of Muscle Cell Differentiation, Skeletal Muscle Fiber Development
Applikationshinweise Optimal working dilutions should be determined experimentally by the investigator.
Kommentare

Antigen size: 590 AA

Beschränkungen Nur für Forschungszwecke einsetzbar
Format Liquid
Konzentration Lot specific
Buffer Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
Konservierungsmittel Sodium azide
Vorsichtsmaßnahmen This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handhabung Avoid repeated freeze-thaw cycles.
Lagerung -20 °C
Informationen zur Lagerung For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
Bilder des Herstellers
Western Blotting (WB) image for anti-Histone Deacetylase 9 (HDAC9) (C-Term) antibody (ABIN2775576) WB Suggested Anti-HDAC9 Antibody Titration: 1.25ug/ml
Positive Control: ...
Chromatin Immunoprecipitation (ChIP) image for anti-Histone Deacetylase 9 (HDAC9) (C-Term) antibody (ABIN2775576) Chromatin Immunoprecipitation (ChIP) Using HDAC9 Antibody - C-terminal region (ARP427...
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) image for anti-Histone Deacetylase 9 (HDAC9) (C-Term) antibody (ABIN2775576) Rabbit Anti-HDAC9 Antibody ,Paraffin Embedded Tissue: Human alveolar cell
Cell...
Produkt verwendet in: Spallotta, Tardivo, Nanni, Rosati, Straino, Mai, Vecellio, Valente, Capogrossi, Farsetti, Martone, Bozzoni, Pontecorvi, Gaetano, Colussi: "Detrimental effect of class-selective histone deacetylase inhibitors during tissue regeneration following hindlimb ischemia." in: The Journal of biological chemistry, Vol. 288, Issue 32, pp. 22915-29, 2013 (PubMed).

Milde, Oehme, Korshunov, Kopp-Schneider, Remke, Northcott, Deubzer, Lodrini, Taylor, von Deimling, Pfister, Witt: "HDAC5 and HDAC9 in medulloblastoma: novel markers for risk stratification and role in tumor cell growth." in: Clinical cancer research : an official journal of the American Association for Cancer Research, Vol. 16, Issue 12, pp. 3240-52, 2010 (PubMed).

Hang, Yang, Han, Cheng, Shang, Ashley, Zhou, Chang: "Chromatin regulation by Brg1 underlies heart muscle development and disease." in: Nature, Vol. 466, Issue 7302, pp. 62-7, 2010 (PubMed).

Allgemeine Veröffentlichungen Han, He, Wu, Liu, Chen: "Mechanism of recruitment of class II histone deacetylases by myocyte enhancer factor-2." in: Journal of molecular biology, Vol. 345, Issue 1, pp. 91-102, 2004 (PubMed).

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