DDX21 Antikörper (C-Term)

Produktnummer ABIN2775198

Produktdetails anti-DDX21 Antikörper

Target: DDX21 (DEAD (Asp-Glu-Ala-Asp) Box Polypeptide 21 (DDX21))

Bindungsspezifität: C-Term

Reaktivität: Human, Ratte, Pferd, Hund, Schwein, Rind (Kuh), Meerschweinchen, Kaninchen

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser DDX21 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Sequenz: FRGQRDGNRR FRGQREGSRG PRGQRSGGGN KSNRSQNKGQ KRSFSKAFGQ

Homologie: Cow: 86%, Dog: 93%, Guinea Pig: 86%, Horse: 93%, Human: 100%, Pig: 93%, Rabbit: 93%, Rat: 93%

Produktmerkmale: This is a rabbit polyclonal antibody against DDX21. It was validated on Western Blot using a cell lysate as a positive control.

Aufreinigung: Protein A purified

Immunogen: The immunogen is a synthetic peptide directed towards the C terminal region of human DDX21

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator.

Kommentare:

Antigen size: 783 AA

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Referenzen für anti-DDX21 Antikörper (ABIN2775198)

Miyazawa, Yoshikawa, Magae, Ishikawa, Izumikawa, Terukina, Suzuki, Nakamura-Fujiyama, Miura, Hayano, Komatsu, Isobe, Takahashi: "Human cell growth regulator Ly-1 antibody reactive homologue accelerates processing of preribosomal RNA." in: Genes to cells : devoted to molecular & cellular mechanisms, Vol. 19, Issue 4, pp. 273-86, (2014) (PubMed).

Romanova, Grand, Zhang, Rayner, Katoku-Kikyo, Kellner, Kikyo: "Critical role of nucleostemin in pre-rRNA processing." in: The Journal of biological chemistry, Vol. 284, Issue 8, pp. 4968-77, (2009) (PubMed).

Details zu DDX21

Target: DDX21 (DEAD (Asp-Glu-Ala-Asp) Box Polypeptide 21 (DDX21))

Andere Bezeichnung: DDX21 (DDX21 Produkte)

Synonyme: MGC130693 antikoerper, DDX21 antikoerper, cb960 antikoerper, wu:fi30c07 antikoerper, wu:fi34d08 antikoerper, GUA antikoerper, GURDB antikoerper, RH-II/GU antikoerper, RH-II/GuA antikoerper, Ddx21a antikoerper, AI255159 antikoerper, AL022742 antikoerper, D10Ertd645e antikoerper, D10Wsu42e antikoerper, DEAD-box helicase 21 L homeolog antikoerper, DExD-box helicase 21 antikoerper, DEAD-box helicase 21 antikoerper, DEAD (Asp-Glu-Ala-Asp) box helicase 21 antikoerper, DEAD (Asp-Glu-Ala-Asp) box polypeptide 21 antikoerper, ddx21.L antikoerper, DDX21 antikoerper, ddx21 antikoerper, Ddx21 antikoerper

Hintergrund: DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. DDX21 encodes a DEAD box protein, which is an antigen recognized by autoimmune antibodies from a patient with watermelon stomach disease. This protein unwinds double-stranded RNA, folds single-stranded RNA, and may play important roles in ribosomal RNA biogenesis, RNA editing, RNA transport, and general transcription.
Alias Symbols: GUA, GURDB, RH-II/GU, RH-II/GuA
Protein Interaction Partner: HUWE1, PA2G4, KPNA3, CEP250, SUMO2, SUMO3, STAU1, IVNS1ABP, UBC, MDM2, LGR4, SUMO1, ERG, WWOX, EED, rev, SRPK2, SRPK3, FBXO6, TARDBP, LYN, AICDA, PAN2, vif, WHSC1, VCAM1, ITGA4, IL7R, FN1, CSNK2A1, YWHAE, SMURF1, H2AFX, APTX, ESR1, FTSJ3, PCDHA2, RRP7A, R
Protein Size: 783

Molekulargewicht: 86 kDa

Gen-ID: 9188

NCBI Accession: NM_004728, NP_004719

UniProt: Q9NR30

Pathways: SARS-CoV-2 Protein Interaktom