CTCFL Antikörper (N-Term)

Produktnummer ABIN2775057

Produktdetails anti-CTCFL Antikörper

Target: CTCFL (CCCTC-Binding Factor (Zinc Finger Protein)-Like (CTCFL))

Bindungsspezifität: N-Term

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser CTCFL Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Sequenz: CREKDHRSPS ELEAERTSGA FQDSVLEEEV ELVLAPSEES EKYILTLQTV

Homologie: Human: 100%

Produktmerkmale: This is a rabbit polyclonal antibody against CTCFL. It was validated on Western Blot using a cell lysate as a positive control.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human CTCFL

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator.

Kommentare:

Antigen size: 663 AA

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Referenzen für anti-CTCFL Antikörper (ABIN2775057)

Sun, Huang, Nguyen, Bisht, Bar-Sela, Ho, Bradbury, Yu, Cui, Lee, Trepel, Feinberg, Gius: "DNA methyltransferase 1 and 3B activate BAG-1 expression via recruitment of CTCFL/BORIS and modulation of promoter histone methylation." in: Cancer research, Vol. 68, Issue 8, pp. 2726-35, (2008) (PubMed).

Details zu CTCFL

Target: CTCFL (CCCTC-Binding Factor (Zinc Finger Protein)-Like (CTCFL))

Andere Bezeichnung: CTCFL (CTCFL Produkte)

Synonyme: BORIS antikoerper, CT27 antikoerper, CTCF-T antikoerper, HMGB1L1 antikoerper, dJ579F20.2 antikoerper, CTCFL antikoerper, Boris antikoerper, OTTMUSG00000016680 antikoerper, CCCTC-binding factor like antikoerper, CCCTC-binding factor (zinc finger protein)-like antikoerper, CTCFL antikoerper, Ctcfl antikoerper

Hintergrund: CCCTC-binding factor (CTCF), an 11-zinc-finger factor involved in gene regulation, utilizes different zinc fingers to bind varying DNA target sites. CTCF forms methylation-sensitive insulators that regulate X-chromosome inactivation. CTCFL is a paralog of CTCF and appears to be expressed primarily in the cytoplasm of spermatocytes, unlike CTCF which is expressed primarily in the nucleus of somatic cells. CTCF and CTCFL are normally expressed in a mutually exclusive pattern that correlates with resetting of methylation marks during male germ cell differentiation.CCCTC-binding factor (CTCF), an 11-zinc-finger factor involved in gene regulation, utilizes different zinc fingers to bind varying DNA target sites. CTCF forms methylation-sensitive insulators that regulate X-chromosome inactivation. This gene is a paralog of CTCF and appears to be expressed primarily in the cytoplasm of spermatocytes, unlike CTCF which is expressed primarily in the nucleus of somatic cells. CTCF and the protein encoded by this gene are normally expressed in a mutually exclusive pattern that correlates with resetting of methylation marks during male germ cell differentiation. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
Alias Symbols: BORIS, CTCF-T, MGC163358, dJ579F20.2, CT27, HMGB1L1
Protein Interaction Partner: SP1, BAG6, HIST2H2AC, HIST1H1A, PRMT7, HIST1H3A, BRCA1,
Protein Size: 663

Molekulargewicht: 76 kDa

Gen-ID: 140690

NCBI Accession: NM_080618, NP_542185

UniProt: Q8NI51