MCM7 Antikörper (Middle Region)

Produktnummer ABIN2774896

Produktdetails anti-MCM7 Antikörper

Target: MCM7 (Minichromosome Maintenance Complex Component 7 (MCM7))

Bindungsspezifität: Middle Region

Reaktivität: Human, Maus, Ratte, Kaninchen, Meerschweinchen, Rind (Kuh), Pferd, Hund

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser MCM7 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Sequenz: LSTALARLRM VDVVEKEDVN EAIRLMEMSK DSLLGDKGQT ARTQRPADVI

Homologie: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 93%, Rabbit: 100%, Rat: 100%

Produktmerkmale: This is a rabbit polyclonal antibody against MCM7. It was validated on Western Blot using a cell lysate as a positive control.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human MCM7

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator.

Kommentare:

Antigen size: 719 AA

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Details zu MCM7

Target: MCM7 (Minichromosome Maintenance Complex Component 7 (MCM7))

Andere Bezeichnung: MCM7 (MCM7 Produkte)

Synonyme: CDC47 antikoerper, MCM2 antikoerper, P1.1-MCM3 antikoerper, P1CDC47 antikoerper, P85MCM antikoerper, PNAS146 antikoerper, MCM7 antikoerper, AI747533 antikoerper, Mcmd7 antikoerper, mCDC47 antikoerper, chunp6911 antikoerper, nyz175 antikoerper, sr:nyz175 antikoerper, cdc47 antikoerper, cdc47-2 antikoerper, mcm7 antikoerper, xmcm7 antikoerper, CG4978 antikoerper, DmMCM7 antikoerper, DmeMCM7 antikoerper, Dmel\\CG4978 antikoerper, McM7 antikoerper, Mcp-PCR1 antikoerper, PCR1 antikoerper, anon-EST:Liang-1.66 antikoerper, clone 1.66 antikoerper, minichromosome maintenance complex component 7 antikoerper, mini-chromosome maintenance complex protein 7 antikoerper, minichromosome maintenance complex component 2 antikoerper, minichromosome maintenance complex component 7 L homeolog antikoerper, Minichromosome maintenance 7 antikoerper, minichromosome maintenance complex component 7 S homeolog antikoerper, MCM complex subunit Mcm7 antikoerper, MCM7 antikoerper, CDC47 antikoerper, Mcm7 antikoerper, MCM2 antikoerper, mcm7 antikoerper, mcm7.L antikoerper, mcm7.S antikoerper

Hintergrund: MCM7 encodes a protein that is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are essential for the initiation of eukaryotic genome replication. The hexameric protein complex formed by the MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. The MCM complex consisting of this protein and MCM2, 4 and 6 proteins possesses DNA helicase activity, and may act as a DNA unwinding enzyme. Cyclin D1-dependent kinase, CDK4, is found to associate with this protein, and may regulate the binding of this protein with the tumorsuppressor protein RB1/RB. The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are essential for the initiation of eukaryotic genome replication. The hexameric protein complex formed by the MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. The MCM complex consisting of this protein and MCM2, 4 and 6 proteins possesses DNA helicase activity, and may act as a DNA unwinding enzyme. Cyclin D1-dependent kinase, CDK4, is found to associate with this protein, and may regulate the binding of this protein with the tumorsuppressor protein RB1/RB. Alternatively spliced transcript variants encoding distinct isoforms have been reported.
Alias Symbols: CDABP0042, CDC47, MCM2, P1.1-MCM3, P1CDC47, P85MCM, PNAS-146, PNAS146
Protein Interaction Partner: AK8, MIPOL1, C8orf34, USHBP1, MCMBP, CCDC102B, TRIM54, MBIP, UBQLN1, TRIM27, NAB2, KIFC3, GOLGA2, PNMA1, UBC, SP2, HAUS2, CEP250, CEP57, SUMO2, SUMO3, PCNA, STAU1, SUZ12, RNF2, MCM4, MCM2, HSP90AB1, PRMT1, PRRC1, CLUH, TOMM34, TRIM16, HYOU1, BAG3, MIB1, P
Protein Size: 719

Molekulargewicht: 81 kDa

Gen-ID: 4176

NCBI Accession: NM_005916, NP_005907

UniProt: P33993

Pathways: DNA Reparatur, Mitotic G1-G1/S Phases, DNA Replication, Chromatin Binding, Synthesis of DNA