TWEAK Antikörper (N-Term)
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- Target Alle TWEAK (TNFSF12) Antikörper anzeigen
- TWEAK (TNFSF12) (Tumor Necrosis Factor (Ligand) Superfamily, Member 12 (TNFSF12))
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Bindungsspezifität
- N-Term
- Reaktivität
- Human, Maus, Ratte, Pferd, Hund, Kaninchen, Zebrafisch (Danio rerio)
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Wirt
- Kaninchen
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Klonalität
- Polyklonal
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Konjugat
- Dieser TWEAK Antikörper ist unkonjugiert
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Applikation
- Western Blotting (WB)
- Sequenz
- LGLLLAVVSL GSRASLSAQE PAQEELVAEE DQDPSELNPQ TEESQDPAPF
- Homologie
- Dog: 79%, Horse: 93%, Human: 100%, Mouse: 83%, Rabbit: 83%, Rat: 86%, Zebrafish: 82%
- Produktmerkmale
- This is a rabbit polyclonal antibody against TNFSF12. It was validated on Western Blot using a cell lysate as a positive control.
- Aufreinigung
- Affinity Purified
- Immunogen
- The immunogen is a synthetic peptide directed towards the N terminal region of human TNFSF12
- Top Product
- Discover our top product TNFSF12 Primärantikörper
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- Applikationshinweise
- Optimal working dilutions should be determined experimentally by the investigator.
- Kommentare
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Antigen size: 249 AA
- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Format
- Liquid
- Konzentration
- Lot specific
- Buffer
- Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
- Konservierungsmittel
- Sodium azide
- Vorsichtsmaßnahmen
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Handhabung
- Avoid repeated freeze-thaw cycles.
- Lagerung
- -20 °C
- Informationen zur Lagerung
- For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
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- Target
- TWEAK (TNFSF12) (Tumor Necrosis Factor (Ligand) Superfamily, Member 12 (TNFSF12))
- Andere Bezeichnung
- TNFSF12 (TNFSF12 Produkte)
- Synonyme
- APO3L antikoerper, DR3LG antikoerper, TWEAK antikoerper, Apo3l antikoerper, Dr3l antikoerper, Dr3lg antikoerper, Tweak antikoerper, TNF superfamily member 12 antikoerper, tumor necrosis factor (ligand) superfamily, member 12 antikoerper, TNFSF12 antikoerper, Tnfsf12 antikoerper
- Hintergrund
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TNFSF12 is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This protein is a ligand for the FN14/TWEAKR receptor. This cytokine has overlapping signaling functions with TNF, but displays a much wider tissue distribution. This cytokine can induce apoptosis via multiple pathways of cell death in a cell type-specific manner. This cytokine is also found to promote proliferation and migration of endothelial cells, and thus acts as a regulator of angiogenesis. Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This protein is a ligand for the FN14/TWEAKR receptor. This cytokine has overlapping signaling functions with TNF, but displays a much wider tissue distribution. This cytokine can induce apoptosis via multiple pathways of cell death in a cell type-specific manner. This cytokine is also found to promote proliferation and migration of endothelial cells, and thus acts as a regulator of angiogenesis. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
Alias Symbols: APO3L, DR3LG, MGC129581, MGC20669, TWEAK
Protein Interaction Partner: DDIT3, TNFSF13B, LYN, OTUB1, TRAF2, BIRC2, AGGF1, TNFRSF12A, TNFRSF25,
Protein Size: 249 - Molekulargewicht
- 17 kDa
- Gen-ID
- 8742
- NCBI Accession
- NM_003809, NP_003800
- UniProt
- O43508
- Pathways
- Apoptose
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