LGMN Antikörper (Middle Region)

Produktnummer ABIN2774455

Produktdetails anti-LGMN Antikörper

Target: LGMN (Legumain (LGMN))

Bindungsspezifität: Middle Region

Reaktivität: Human, Maus, Ratte, Rind (Kuh), Hund, Kaninchen, Meerschweinchen, Pferd, Zebrafisch (Danio rerio), Schaf, Schwein

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser LGMN Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Sequenz: ESSYACYYDE KRSTYLGDWY SVNWMEDSDV EDLTKETLHK QYHLVKSHTN

Homologie: Cow: 100%, Dog: 100%, Guinea Pig: 79%, Horse: 93%, Human: 100%, Mouse: 100%, Pig: 86%, Rabbit: 100%, Rat: 100%, Sheep: 100%, Zebrafish: 93%

Produktmerkmale: This is a rabbit polyclonal antibody against LGMN. It was validated on Western Blot.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of Human LGMN

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator.

Kommentare:

Antigen size: 433 AA

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Details zu LGMN

Target: LGMN (Legumain (LGMN))

Andere Bezeichnung: LGMN (LGMN Produkte)

Synonyme: AEP antikoerper, LGMN1 antikoerper, PRSC1 antikoerper, AI746452 antikoerper, AU022324 antikoerper, Prsc1 antikoerper, MGC64351 antikoerper, cb173 antikoerper, cb460 antikoerper, sb:cb173 antikoerper, zgc:76953 antikoerper, wu:fa98g05 antikoerper, wu:fj92g08 antikoerper, lgmn antikoerper, MGC88980 antikoerper, DELTA VACUOLAR PROCESSING ENZYME antikoerper, DELTAVPE antikoerper, delta vacuolar processing enzyme antikoerper, legumain antikoerper, legumain L homeolog antikoerper, delta vacuolar processing enzyme antikoerper, Legumain antikoerper, LGMN antikoerper, Lgmn antikoerper, lgmn.L antikoerper, lgmn antikoerper, DELTA-VPE antikoerper, MBOO_RS07785 antikoerper, Odosp_3582 antikoerper, LOC569153 antikoerper

Hintergrund: This gene encodes a cysteine protease that has a strict specificity for hydrolysis of asparaginyl bonds. This enzyme may be involved in the processing of bacterial peptides and endogenous proteins for MHC class II presentation in the lysosomal/endosomal systems. Enzyme activation is triggered by acidic pH and appears to be autocatalytic. Protein expression occurs after monocytes differentiate into dendritic cells. A fully mature, active enzyme is produced following lipopolysaccharide expression in mature dendritic cells. Overexpression of this gene may be associated with the majority of solid tumor types. This gene has a pseudogene on chromosome 13. Several alternatively spliced transcript variants have been described, but the biological validity of only two has been determined.
Alias Symbols: AEP, LGMN1, PRSC1
Protein Interaction Partner: USP17L2, TRAF6, USP17L9P, SUMO1, UBC, NEDD8, LAMC3, ACIN1, IGF2BP3, HNRNPR, FBXO6, ISG15, LGMN,
Protein Size: 433

Molekulargewicht: 48 kDa

Gen-ID: 5641

NCBI Accession: NM_005606, NP_005597

UniProt: Q99538

Pathways: Metabolism of Steroid Hormones and Vitamin D, Activation of Innate immune Response, Toll-Like Receptors Cascades