CYP2A6 Antikörper (C-Term)

Produktnummer ABIN2774279

Produktdetails anti-CYP2A6 Antikörper

Target: CYP2A6 (Cytochrome P450, Family 2, Subfamily A, Polypeptide 6 (CYP2A6))

Bindungsspezifität: C-Term

Reaktivität: Human, Maus, Ratte, Pferd, Rind (Kuh), Hund, Meerschweinchen, Kaninchen, Schaf

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser CYP2A6 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Sequenz: MEAVIHEIQR FGDVIPMSLA RRVKKDTKFR DFFLPKGTEV YPMLGSVLRD

Homologie: Cow: 92%, Dog: 86%, Guinea Pig: 92%, Horse: 92%, Human: 100%, Mouse: 92%, Rabbit: 85%, Rat: 92%, Sheep: 92%

Produktmerkmale: This is a rabbit polyclonal antibody against CYP2A6. It was validated on Western Blot.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the C-terminal region of Human CYP2A6

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator.

Kommentare:

Antigen size: 494 AA

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Details zu CYP2A6

Target: CYP2A6 (Cytochrome P450, Family 2, Subfamily A, Polypeptide 6 (CYP2A6))

Andere Bezeichnung: CYP2A6 (CYP2A6 Produkte)

Synonyme: CPA6 antikoerper, CYP2A antikoerper, CYP2A3 antikoerper, CYPIIA6 antikoerper, P450C2A antikoerper, P450PB antikoerper, cyp2a6 antikoerper, cytochrome P450 family 2 subfamily A member 6 antikoerper, cytochrome P450 2A6 antikoerper, cytochrome P450 family 2 subfamily A member 6 L homeolog antikoerper, CYP2A6 antikoerper, cyp2a6.L antikoerper

Hintergrund: CYP2A6 is a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by phenobarbital. The enzyme is known to hydroxylate coumarin, and also metabolizes nicotine, aflatoxin B1, nitrosamines, and some pharmaceuticals. Individuals with certain allelic variants are said to have a poor metabolizer phenotype, meaning they do not efficiently metabolize coumarin or nicotine. This gene is part of a large cluster of cytochrome P450 genes from the CYP2A, CYP2B and CYP2F subfamilies on chromosome 19q. The gene was formerly referred to as CYP2A3, however, it has been renamed CYP2A6.
Alias Symbols: CPA6, CYP2A, CYP2A3, P450C2A, P450PB, CYPIIA6
Protein Interaction Partner: POR, CYB5A,
Protein Size: 494

Molekulargewicht: 56 kDa

Gen-ID: 1548

NCBI Accession: NM_000762, NP_000753

UniProt: P11509