Arginase, Liver (ARG1) (N-Term) Antikörper

Details zu Produkt Nr. ABIN2773866, Anbieter: Anmelden zum Anzeigen
Antigen
  • SI:zC146F4.4 (novel protein with NUDIX domain)
  • si:ch211-146f4.3
  • argi1
  • AI
  • AI256583
  • Arg-1
  • PGIF
  • arginase 1
  • arginase
  • Arginase-1
  • arginase, liver
  • L-arginase
  • arg1
  • PGTG_16455
  • argi1
  • ARG1
  • Arg1
Epitop
N-Term
70
42
18
18
9
7
7
7
5
5
3
3
3
2
2
2
2
1
1
1
1
1
1
1
1
1
Reaktivität
Rind (Kuh), Hund, Ziege, Meerschweinchen, Pferd, Human, Maus, Schwein, Kaninchen, Ratte (Rattus)
196
80
71
23
15
13
7
4
3
2
2
2
1
1
Wirt
Kaninchen
158
48
42
10
4
Klonalität
Polyklonal
Konjugat
Unkonjugiert
13
13
10
8
8
7
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
Applikation
Immunohistochemistry (IHC), Western Blotting (WB)
203
120
46
43
36
22
22
13
5
4
3
2
2
2
1
1
1
1
1
1
Optionen
Hersteller
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Hersteller Produkt- Nr.
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Immunogen The immunogen is a synthetic peptide directed towards the N terminal region of human ARG1
Sequenz HSLAIGSISG HARVHPDLGV IWVDAHTDIN TPLTTTSGNL HGQPVSFLLK
Kreuzreaktivität Rind (Kuh), Hund, Human, Maus, Schwein, Kaninchen, Ratte (Rattus)
Homologie Cow: 100%, Dog: 100%, Goat: 100%, Guinea Pig: 93%, Horse: 100%, Human: 100%, Mouse: 93%, Pig: 100%, Rabbit: 86%, Rat: 100%
Produktmerkmale This is a rabbit polyclonal antibody against ARG1. It was validated on Western Blot and immunohistochemistry.
Reinigung Protein A purified
Andere Bezeichnung Arginase-1 (ARG1 Antibody Abstract)
Hintergrund Arginase catalyzes the hydrolysis of arginine to ornithine and urea. The type I isoform of ARG1, is a cytosolic enzyme and expressed predominantly in the liver as a component of the urea cycle. Inherited deficiency of this enzyme results in argininemia, an autosomal recessive disorder characterized by hyperammonemia.Arginase catalyzes the hydrolysis of arginine to ornithine and urea. At least two isoforms of mammalian arginase exist (types I and II) which differ in their tissue distribution, subcellular localization, immunologic crossreactivity and physiologic function. The type I isoform encoded by this gene, is a cytosolic enzyme and expressed predominantly in the liver as a component of the urea cycle. Inherited deficiency of this enzyme results in argininemia, an autosomal recessive disorder characterized by hyperammonemia.
Protein Interaction Partner: RPA3, RPA2, RPA1, SUZ12, EZH2, BMI1, ALDH4A1, ESR1, RAD21, UBC, UCHL5, ATG101, USP53, FLOT1, NOS1, ARG2,
Protein Size: 322
Molekulargewicht 35 kDa
Gen-ID 383
NCBI Accession NM_000045, NP_000036
UniProt P05089
Pathways Cellular Response to Molecule of Bacterial Origin
Applikationshinweise Optimal working dilutions should be determined experimentally by the investigator.
Kommentare

Antigen size: 322 AA

Beschränkungen Nur für Forschungszwecke einsetzbar
Format Liquid
Konzentration Lot specific
Buffer Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
Konservierungsmittel Sodium azide
Vorsichtsmaßnahmen This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handhabung Avoid repeated freeze-thaw cycles.
Lagerung -20 °C
Informationen zur Lagerung For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
Bilder des Herstellers
Immunohistochemistry (IHC) image for anti-Arginase, Liver (ARG1) (N-Term) antibody (ABIN2773866) anti-Arginase, Liver (ARG1) (N-Term) antibody
Produkt verwendet in: Hu, Lausted, Yoo, Yan, Brightman, Chen, Wang, Bu, Hood: "Quantitative liver-specific protein fingerprint in blood: a signature for hepatotoxicity." in: Theranostics, Vol. 4, Issue 2, pp. 215-28, 2014 (PubMed).

Allgemeine Veröffentlichungen Orellana, López, Uribe, Fuentes, Salas, Carvajal: "Insights into the interaction of human liver arginase with tightly and weakly bound manganese ions by chemical modification and site-directed mutagenesis studies." in: Archives of biochemistry and biophysics, Vol. 403, Issue 2, pp. 155-9, 2002 (PubMed).

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