NR1H4 Antikörper (Middle Region)

Produktnummer ABIN2773865

Produktdetails anti-NR1H4 Antikörper

Target: NR1H4 (Nuclear Receptor Subfamily 1, Group H, Member 4 (NR1H4))

Bindungsspezifität: Middle Region

Reaktivität: Human, Ratte, Maus, Hund, Pferd, Rind (Kuh), Kaninchen, Schwein, Meerschweinchen

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser NR1H4 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Sequenz: SAVEAMFLRS AEIFNKKLPS GHSDLLEERI RNSGISDEYI TPMFSFYKSI

Homologie: Cow: 93%, Dog: 93%, Guinea Pig: 86%, Horse: 93%, Human: 100%, Mouse: 93%, Pig: 93%, Rabbit: 93%, Rat: 93%

Produktmerkmale: This is a rabbit polyclonal antibody against NR1H4. It was validated on Western Blot using a cell lysate as a positive control.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human NR1H4

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator.

Kommentare:

Antigen size: 472 AA

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Referenzen für anti-NR1H4 Antikörper (ABIN2773865)

Yamada, Osawa, Hamaya, Furuta, Hishida, Kajimura, Ikuma: "Guggulsterone suppresses bile acid-induced and constitutive caudal-related homeobox 2 expression in gut-derived adenocarcinoma cells." in: Anticancer research, Vol. 30, Issue 6, pp. 1953-60, (2010) (PubMed).

Details zu NR1H4

Target: NR1H4 (Nuclear Receptor Subfamily 1, Group H, Member 4 (NR1H4))

Andere Bezeichnung: NR1H4 (NR1H4 Produkte)

Synonyme: zgc:110190 antikoerper, zgc:92742 antikoerper, NR1H4 antikoerper, BAR antikoerper, FXR antikoerper, HRR-1 antikoerper, HRR1 antikoerper, RIP14 antikoerper, AI957360 antikoerper, Fxr antikoerper, Rxrip14 antikoerper, nuclear receptor subfamily 1, group H, member 5 S homeolog antikoerper, nuclear receptor subfamily 1, group H, member 4 antikoerper, nuclear receptor subfamily 1 group H member 4 antikoerper, nr1h5.S antikoerper, nr1h4 antikoerper, NR1H4 antikoerper, Nr1h4 antikoerper

Hintergrund: NR1H4 is the receptor for bile acids such as chenodeoxycholic acid, lithocholic acid and deoxycholic acid. NR1H4 represses the transcription of the cholesterol 7-alpha-hydroxylase gene (CYP7A1) through the induction of NR0B2 or FGF19 expression, via two d
Alias Symbols: BAR, FXR, HRR-1, HRR1, MGC163445, RIP14
Protein Interaction Partner: SMARCD3, HDAC6, SUMO1, NCOR2, ESR1, RRM2, GPS2, RXRG, GAPDH, RXRA, EP300, SIRT1, SRC, NCOA6, CARM1, HIST1H4A, HIST1H3A, PRMT1, NCOR1, XRCC5, PRKDC, XRCC6, NCOA1, CASP8, SMARCD1,
Protein Size: 472

Molekulargewicht: 54 kDa

Gen-ID: 9971

NCBI Accession: NM_005123, NP_005114

UniProt: B6ZGS9

Pathways: Nuclear Receptor Transcription Pathway, Steroid Hormone Mediated Signaling Pathway, Regulation of Carbohydrate Metabolic Process