FASL Antikörper

Produktnummer ABIN2749049

Produktdetails anti-FASL Antikörper

Target: FASL (Fas Ligand (TNF Superfamily, Member 6) (FASL))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser FASL Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Flow Cytometry (FACS), Immunoprecipitation (IP), Immunocytochemistry (ICC)

Spezifität: The mouse monoclonal antibody NOK-1 recognizes an extracellular epitope of CD178 / Fas-L, an approximately 40 kDa transmembrane glycoprotein expressed on neutrophils, monocytes, and activated T and NK cells.

Kreuzreaktivität (Details): Human

Aufreinigung: Purified by protein-A affinity chromatography.

Reinheit: > 95 % (by SDS-PAGE)

Immunogen: L5178Y mouse T lymphoma cells expressing recombinant human CD178

Klon: NOK-1

Isotyp: IgG1

Anwendungsinformationen

Applikationshinweise: Flow cytometry: Recommended dilution: 1-4 μg/mL

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1 mg/mL

Buffer: Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C

Informationen zur Lagerung: Store at 2-8°C. Do not freeze.

Referenzen für anti-FASL Antikörper (ABIN2749049)

Ji, Chen, Braciale, Cloyd: "Apoptosis induced in HIV-1-exposed, resting CD4+ T cells subsequent to signaling through homing receptors is Fas/Fas ligand-mediated." in: Journal of leukocyte biology, Vol. 81, Issue 1, pp. 297-305, (2006) (PubMed).

Jodo, Pidiyar, Xiao, Furusaki, Sharma, Koike, Ju: "Fas ligand (CD178) cytoplasmic tail is a positive regulator of Fas ligand-mediated cytotoxicity." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 174, Issue 8, pp. 4470-4, (2005) (PubMed).

Chopin, Barei-Moniri, Maillé, Le Frère-Belda, Muscatelli-Groux, Merendino, Lecerf, Stoppacciaro, Velotti: "Human urinary bladder transitional cell carcinomas acquire the functional Fas ligand during tumor progression." in: The American journal of pathology, Vol. 162, Issue 4, pp. 1139-49, (2003) (PubMed).

Ghadimi, Sanzenbacher, Thiede, Wenzel, Jing, Plomann, Borkhardt, Kabelitz, Janssen: "Identification of interaction partners of the cytosolic polyproline region of CD95 ligand (CD178)." in: FEBS letters, Vol. 519, Issue 1-3, pp. 50-8, (2002) (PubMed).

Kayagaki, Kawasaki, Ebata, Ohmoto, Ikeda, Inoue, Yoshino, Okumura, Yagita: "Metalloproteinase-mediated release of human Fas ligand." in: The Journal of experimental medicine, Vol. 182, Issue 6, pp. 1777-83, (1996) (PubMed).

Details zu FASL

Target: FASL (Fas Ligand (TNF Superfamily, Member 6) (FASL))

Andere Bezeichnung: CD178 / Fas-L (FASL Produkte)

Hintergrund: Fas ligand,CD178 / Fas-L (Fas ligand, CD95L), a member of TNF family transmembrane glycoproteins, is responsible for induction of apoptosis in cells containing its receptor CD95 / Fas. The CD178-mediated apoptosis pathway has been implicated in peripheral tolerance, tissue pathology, and maintenance of the immune privileged sites. Defects in this interaction may be related to some cases of systemic lupus erythematosus (SLE). CD178 was also described as a co-stimulatory receptor for T-cell activation in mice in vivo.,APTL, FASL, FAS-ligand, CD95L, TNFSF6, TNLG1A

Gen-ID: 356

UniProt: P48023

Pathways: Apoptose, EGFR Signaling Pathway, Production of Molecular Mediator of Immune Response, Positive Regulation of Endopeptidase Activity