MLX Antikörper

Produktnummer ABIN272258

Produktdetails anti-MLX Antikörper

Target: MLX (MAX-Like Protein X (MLX))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser MLX Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Spezifität: This antibody detects endogenous levels of Mlx protein. (region surrounding Gln136)

Kreuzreaktivität (Details): Species reactivity (expected):Mouse and Rat.
Species reactivity (tested):Human.

Aufreinigung: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen

Reinheit: > 95 % pure by SDS-PAGE

Anwendungsinformationen

Applikationshinweise: ELISA: 1: 10000approx. 1: 20000. WB: 1: 500approx. 1: 1000.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1,0 mg/mL

Buffer: Phosphate buffered saline (PBS), pH 7.2., 0.05 % sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: DO NOT FREEZE!

Lagerung: 4 °C

Informationen zur Lagerung: Store the antibody undiluted at 2-8 °C.

Details zu MLX

Target: MLX (MAX-Like Protein X (MLX))

Andere Bezeichnung: Max-Like Protein X (MLX Produkte)

Synonyme: MAD7 antikoerper, MXD7 antikoerper, TCFL4 antikoerper, bHLHd13 antikoerper, Tcfl4 antikoerper, im:7146242 antikoerper, wu:fb61a01 antikoerper, wu:fb99c01 antikoerper, zgc:112409 antikoerper, DKFZp468J1719 antikoerper, MLX, MAX dimerization protein antikoerper, MAX-like protein X antikoerper, max-like protein X antikoerper, MLX antikoerper, Mlx antikoerper, mlx antikoerper, LOC786043 antikoerper

Hintergrund: Max is a nuclear localized bHLH-Zip protein that forms homodimers or heterodimers with Myc family members, including Myc, Mad 1, Mad 3, Mad 4, Mxi1 and Mnt (or Rox). These dimers bind to the E-box sequence CACGTG in order to regulate cell growth, proliferation and apoptosis. Mlx (Max-like protein X) is a bHLH-Zip protein that is structurally and functionally related to Max. Like Max, Mlx is broadly expressed in many tissues and has a long half-life. Mlx also forms homodimers or heterodimers with members of the Myc family, specifically Mad 1, Mad 4 and Rox, and members of the Mondo family, to repress or activate transcription from CACGTG E-boxes. MondoA forms weak homodimers and preferentially forms heterodimers with Mlx. The MondoA/Mlx complex is primarily localized to the cytoplasm, but will translocate to the nucleus in response to leptomycin B. Mlx can also dimerize with WBSCR14, a protein involved in Williams-Beuren syndrome (WBS), to repress E-box transcription, which provides further evidence that Mlx is a critical element in a transcription factor network.Synonyms: BigMax protein, MLX, Max-like bHLHZip protein, TCFL4, Transcription factor-like protein 4

Molekulargewicht: approx. 33 kDa

Gen-ID: 6945

NCBI Accession: NP_733752

UniProt: Q9UH92