TLE4 Antikörper

Produktnummer ABIN272213

Produktdetails anti-TLE4 Antikörper

Target: TLE4 (Transducin-like Enhancer Protein 4 (TLE4))

Reaktivität: Human, Ratte, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser TLE4 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Enzyme Immunoassay (EIA)

Spezifität: This antibody detects endogenous levels of TLE4 protein. (region surrounding His190)

Kreuzreaktivität (Details): Species reactivity (expected):Mouse and Rat.
Species reactivity (tested):Human.

Aufreinigung: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen

Reinheit: > 95 % pure by SDS-PAGE

Anwendungsinformationen

Applikationshinweise: ELISA: 1: 20000approx. 1: 40000. WB: 1: 500approx. 1: 1000.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1,0 mg/mL

Buffer: Phosphate buffered saline (PBS), pH 7.2., 0.05 % sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: DO NOT FREEZE!

Lagerung: 4 °C

Informationen zur Lagerung: Store the antibody undiluted at 2-8 °C.

Details zu TLE4

Target: TLE4 (Transducin-like Enhancer Protein 4 (TLE4))

Andere Bezeichnung: TLE4 (TLE4 Produkte)

Synonyme: TLE4 antikoerper, NV17443 antikoerper, BCE-1 antikoerper, BCE1 antikoerper, E(spI) antikoerper, ESG antikoerper, ESG4 antikoerper, GRG4 antikoerper, Esp2 antikoerper, Grg4 antikoerper, XGrg-4 antikoerper, XTCF-4 antikoerper, Xgrg4 antikoerper, Xtle4 antikoerper, esg4 antikoerper, grg4 antikoerper, gro antikoerper, 5730411M05Rik antikoerper, AA792082 antikoerper, Bce-1 antikoerper, Bce1 antikoerper, ESTM13 antikoerper, ESTM14 antikoerper, X83332 antikoerper, X83333 antikoerper, transducin like enhancer of split 4 antikoerper, transducin-like enhancer protein 4 antikoerper, protein groucho-1 antikoerper, transducin-like enhancer of split 4 antikoerper, transducin like enhancer of split 4-Z 1 antikoerper, transducin like enhancer of split 4 S homeolog antikoerper, TLE4 antikoerper, LOC706619 antikoerper, LOC100117159 antikoerper, LOC100462498 antikoerper, Tle4 antikoerper, TLE4Z1 antikoerper, LOC476317 antikoerper, tle4.S antikoerper

Hintergrund: The Notch signaling pathway controls cellular interactions important for the specification of a variety of fates in both invertebrates and vertebrates. Key players in the Notch pathway are the TLE genes (for transducin-like enhancer of split, also designated ESG for enhancer of split groucho), which are human homologs of the Drosophila groucho gene. Groucho is a transcriptional repressor that plays a key role in neurogenesis, segmentation and sex determination. TLEs associate with chromatin in live cells and specifically with Histone H3, but not with other core histones. Expression of the TLE genes, TLE1, TLE2, TLE3 and TLE4, correlate with immature epithelial cells that are progressing toward a terminally differentiated state, suggesting a role during epithelial differentiation. TLE1, TLE2 and TLE3 have elevated expression in cervial squamous metaplasias and carcinomas, while TLE4 is most highly expressed in the brain, particularly in the caudate nucleus. TLE1 and TLE4 contain SP and WD40 domains, through which TLE1 binds AML1 to inhibit AML1-induced transactivation of the CSF1 receptor. In early stages of cell differentiation, TLE1 is up-regulated, and TLE2 and TLE4 are down-regulated.Synonyms: GRG4, Groucho-related protein 4, KIAA1261, Transducin-like enhancer protein 4

Molekulargewicht: approx. 83 kDa

Gen-ID: 7091

NCBI Accession: NP_008936

UniProt: Q04727

Pathways: WNT Signalweg