EGR2 Antikörper

Produktnummer ABIN272177

Produktdetails anti-EGR2 Antikörper

Target: EGR2 (Early Growth Response 2 (EGR2))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser EGR2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Spezifität: This antibody detects endogenous levels of Egr-2 protein. (region surrounding Arg409)

Kreuzreaktivität (Details): Species reactivity (expected):Mouse and Rat.
Species reactivity (tested):Human.

Aufreinigung: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen

Reinheit: > 95 % pure by SDS-PAGE

Anwendungsinformationen

Applikationshinweise: ELISA: 1: 20000approx. 1: 40000. WB: 1: 500approx. 1: 1000.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1,0 mg/mL

Buffer: Phosphate buffered saline (PBS), pH 7.2., 0.05 % sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: DO NOT FREEZE!

Lagerung: 4 °C

Informationen zur Lagerung: Store the antibody undiluted at 2-8 °C.

Details zu EGR2

Target: EGR2 (Early Growth Response 2 (EGR2))

Andere Bezeichnung: EGR2 (EGR2 Produkte)

Synonyme: AT591 antikoerper, CMT1D antikoerper, CMT4E antikoerper, KROX20 antikoerper, Egr-2 antikoerper, Krox-20 antikoerper, Krox20 antikoerper, NGF1-B antikoerper, Zfp-25 antikoerper, Zfp-6 antikoerper, KRX-20 antikoerper, cb427 antikoerper, egr2 antikoerper, id:ibd5073 antikoerper, krox20 antikoerper, krx20 antikoerper, wu:fb71h10 antikoerper, zgc:92210 antikoerper, frb35 antikoerper, early growth response 2 antikoerper, early growth response 2b antikoerper, early growth response 2a antikoerper, EGR2 antikoerper, Egr2 antikoerper, egr2b antikoerper, egr2a antikoerper

Hintergrund: Egr proteins function in transcription regulatory activities surrounding cellular growth, differentiation and function. The deduced amino acid sequences of human Egr-2 and mouse Egr-1 are 92 % identical in the zinc finger region but show no homology elsewhere. Egr-2 is a sequence-specific DNA-binding transcription factor that binds two specific DNA sites located in the promoter region of HoxA4 and localizes to the nucleus. Defects in the Egr-2 protein are a cause of congenital hypomyelination neuropathy (CHN). CHN is characterized clinically by early onset of hypotonia, areflexia, distal muscle weakness and very slow nerve conduction velocities. Mutations in the gene that encodes Egr-2 (EGR2) also cause of Dejerine-Sottas syndrome (DSS), which is also known as Dejerine-Sottas neuropathy (DSN) or hereditary motor and sensory neuropathy III (HMSN3). DSS patients exhibit severe early onset motor and sensory neuropathy with very slow nerve conduction velocities and elevated cerebrospinal fluid protein concentrations.Synonyms: AT591, EGR-2, Early growth response protein 2, KROX20, Krox 20, Zinc finger protein Krox-20

Molekulargewicht: approx. 50 kDa

Gen-ID: 1959

NCBI Accession: NP_000390

UniProt: P11161