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PTTG1 Antikörper

PTTG1 Reaktivität: Human WB, IF, IHC (p) Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN272154
  • Target Alle PTTG1 Antikörper anzeigen
    PTTG1 (Pituitary Tumor-Transforming 1 (PTTG1))
    Reaktivität
    • 47
    • 12
    • 11
    • 1
    Human
    Wirt
    • 36
    • 11
    • 1
    Kaninchen
    Klonalität
    • 30
    • 18
    Polyklonal
    Konjugat
    • 30
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    Dieser PTTG1 Antikörper ist unkonjugiert
    Applikation
    • 23
    • 18
    • 12
    • 9
    • 8
    • 3
    • 3
    • 2
    • 2
    • 2
    • 1
    Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
    Spezifität
    This antibody detects endogenous levels of PTTG1/2/3 protein. (region surrounding Leu149)
    Kreuzreaktivität (Details)
    Species reactivity (tested):Human.
    Aufreinigung
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen
    Reinheit
    > 95 % pure by SDS-PAGE
    Top Product
    Discover our top product PTTG1 Primärantikörper
  • Applikationshinweise
    ELISA: 1: 20000approx. 1: 40000. WB: 1: 500approx. 1: 1000.
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Konzentration
    1,0 mg/mL
    Buffer
    Phosphate buffered saline (PBS), pH 7.2., 0.05 % sodium azide
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handhabung
    DO NOT FREEZE!
    Lagerung
    4 °C
    Informationen zur Lagerung
    Store the antibody undiluted at 2-8 °C.
  • Target
    PTTG1 (Pituitary Tumor-Transforming 1 (PTTG1))
    Andere Bezeichnung
    Securin / PTTG1 (PTTG1 Produkte)
    Synonyme
    EAP1 antikoerper, HPTTG antikoerper, PTTG antikoerper, TUTR1 antikoerper, PTTG1 antikoerper, securin antikoerper, AW555095 antikoerper, C87862 antikoerper, Pttg antikoerper, Pttg3 antikoerper, Securin antikoerper, Protein Cut2 antikoerper, pituitary tumor-transforming 1 antikoerper, pituitary tumor-transforming gene 1 antikoerper, securin, sister chromatid separation inhibitor antikoerper, PTTG1 antikoerper, Pttg1 antikoerper, cut2 antikoerper
    Hintergrund
    The product of the oncogene PTTG, pituitary tumor transforming gene, is a human homolog of the anaphase-inhibitor vertebrate protein, securin. PTTG is a 22 kDa protein that contains a basic amino-terminal domain and an acidic carboxy-terminal domain, which acts as a transactivation domain when fused to a heterologous DNA binding domain. Human PTTG is overexpressed in Jurkat and is also detected in human thymus, testis, and placenta. PTTG is mainly expressed in the cytoplasm and is also partially localized to the nucleus. Vertebrate PTTG regulates the separin Esp1, which promotes chromatid separation, to overcome the cohesive forces that hold sister chromatids together. This regulatory function of PTTG suggests that defective regulation of cohesion may contribute to cancer by promoting chromosome instability. Although vertebrate PTTG shares cell-cycle functions with its yeast securin counterparts Pds1p and Cut2, none share sequence homology.
    Molekulargewicht
    approx. 30 kDa
    Gen-ID
    9232
    NCBI Accession
    NP_004210
    UniProt
    O95997
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