BTB and CNC Homology 1, Basic Leucine Zipper Transcription Factor 1 (BACH1) Antikörper

Antigen: BTB and CNC Homology 1, Basic Leucine Zipper Transcription Factor 1 (BACH1)

Synonyme: BACH-1, BACH1, MGC112205, zgc:112205

Klonalität: Polyklonal

Wirt: Kaninchen

Reaktivität: Human

Applikation: Enzyme Immunoassay (EIA), Western Blot (WB)

Produktnummer: ABIN272133

Produktbeschreibung

Produktmerkmale: Synonyms: HA2303, Transcription regulator protein BACH1, BTB and CNC homolog 1, basic leucinezipper transcription factor 1

Weitere Bezeichnung: BACH1

Swiss-Prot: O14867

Kreuzreaktivität: Human

Beschreibung: Members of the small Maf family (MafK, MafF, and MafG) are basic region leucine zipper(bZip) proteins that can function as transcriptional activators or repressors. They dimerizewith other proteins and bind DNA to either represse or activate transcription depending onthe dimer compositions. BACH1 and BACH2, heterodimerization partners of MafK, aremembers of a novel family of BTB/POZ-basic region leucine zipper (bzip) factors. BACH1and BACH2 have significant similarity to each other in BTB domain and Cap‘n' collar-typebZip domain but are otherwise divergent. BACH1 appears ubiquitous, whereas BACH2 isrestricted to monocytes, neuronal cells and is abundantly expressed in the early stages ofB-cell differentiation. BACH2, a 841 amino acid polypeptide, is an Nrf2-related transcriptionrepressor and a tissue-specific partner of the Maf oncoprotein family. In culture cells,BACH2 is localized to the cytoplasm through its C-terminal cytoplasmic localization signal(CLS). Oxidative stressors aborted the CLS activity and induce nuclear accumulation ofBACH2, which mediates nucleocytoplasmic communciation to couple oxidative stress andtranscription repression in mammalian cells. BACH2 heterodimerizes with MAZR throughits BTB/POZ domain to activate transcription. BACH2 also plays an important role in theregulation of B cell development.

Spezifität: BACH1 (L160) antibody detects endogenous levels of BACH1 protein. Species: Human. Others not tested.

Anwendungen

Applikationshinweise: ELISA: 1: 20000~140000. WB: 1: 500~1: 1000. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.

Konzentration: 1,0 mg/ml

Reinigung: Aff - Purified

Buffer: Phosphate buffered saline (PBS) with 15 mM sodium azide, approx. pH 7.2.

Lagerung: Store the antibody undiluted at 2-8°C. DO NOT FREEZE! Shelf life: one year from despatch.

Beschränkungen: Nur für Forschungszwecke einsetzbar