PEA15 Antikörper
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- Target Alle PEA15 Antikörper anzeigen
- PEA15 (phosphoprotein Enriched in Astrocytes 15 (PEA15))
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Reaktivität
- Human, Maus, Ratte
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Wirt
- Kaninchen
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Klonalität
- Polyklonal
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Konjugat
- Dieser PEA15 Antikörper ist unkonjugiert
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Applikation
- Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
- Spezifität
- This antibody detects endogenous levels of PEA-15 protein. (region surrounding Asp110)
- Kreuzreaktivität (Details)
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Species reactivity (expected):Mouse and Rat.
Species reactivity (tested):Human. - Aufreinigung
- The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen
- Reinheit
- > 95 % pure by SDS-PAGE
- Top Product
- Discover our top product PEA15 Primärantikörper
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- Applikationshinweise
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ELISA: 1: 40000approx. 1: 60000. WB: 1: 500approx. 1: 1000. IHC: 1: 50approx. 1: 200. IF: 1: 50approx. 1: 200.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. - Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Konzentration
- 1,0 mg/mL
- Buffer
- Phosphate buffered saline (PBS, pH 7.2., 0.05 % sodium azide
- Konservierungsmittel
- Sodium azide
- Vorsichtsmaßnahmen
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Handhabung
- DO NOT FREEZE!
- Lagerung
- 4 °C
- Informationen zur Lagerung
- Store the antibody undiluted at 2-8 °C.
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- Target
- PEA15 (phosphoprotein Enriched in Astrocytes 15 (PEA15))
- Andere Bezeichnung
- PEA15 (PEA15 Produkte)
- Synonyme
- HMAT1 antikoerper, HUMMAT1H antikoerper, MAT1 antikoerper, MAT1H antikoerper, PEA-15 antikoerper, PED antikoerper, Pea15a antikoerper, PEA15 antikoerper, DKFZp459O1410 antikoerper, proliferation and apoptosis adaptor protein 15 antikoerper, phosphoprotein enriched in astrocytes 15 antikoerper, proliferation and apoptosis adaptor protein 15 L homeolog antikoerper, Astrocytic phosphoprotein PEA-15 antikoerper, PEA15 antikoerper, Pea15 antikoerper, pea15.L antikoerper, pea15 antikoerper
- Hintergrund
- PEA-15 (phosphoprotein enriched in astrocytes) exists in an non-phosphorylated form (N), and two phosphorylated forms, Pa and Pb. PEA-15 is an endogenous substrate for PKC, which mediates the transition from Pa to Pb. The level of PEA-15 phosphorylation changes upon depolymerization or stabilization of tubulins, indicating that PEA-15 co-localizes with microtubules. The first 80 amino acids of PEA-15 correspond to the death effector domain (DED), which is a domain found in proteins that regulate apoptotic signaling pathways. The DED domain is necessary for PEA-15 to block Ras suppression. Although PEA-15 is predominantly expressed in the central nervous system, low levels of PEA-15 are expressed in liver and kidney, and higher levels in muscle. PEA-15 is also referred to as PED, phosphoprotein enriched in diabetes, for its elevated expression in type 2 diabetic patients.Synonyms: Astrocytic phosphoprotein PEA-15, PED, Phosphoprotein enriched in diabetes
- Molekulargewicht
- approx. 36 kDa
- Gen-ID
- 8682
- NCBI Accession
- NP_003759
- UniProt
- Q15121
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