Neutrophil Cytosolic Factor 4, 40kDa (NCF4) Antikörper

Details zu Produkt Nr. ABIN272048, Anbieter: Anmelden zum Anzeigen
Antigen
  • p40phox
  • AI451400
  • NCF
  • P40PHOX
  • SH3PXD4
  • p40phox protein
  • neutrophil cytosolic factor 4
  • neutrophil cytosolic factor 4, 40kDa
  • p40phox
  • LOC100136241
  • Ncf4
  • NCF4
Reaktivität
Human, Maus
117
57
44
7
7
5
4
4
3
3
Wirt
Kaninchen
90
20
11
Klonalität
Polyklonal
Konjugat
Unkonjugiert
3
3
3
2
2
2
2
2
2
2
2
2
2
2
1
1
1
Applikation
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
75
41
33
26
22
5
4
3
3
2
2
1
Optionen
Hersteller
Anmelden zum Anzeigen
Hersteller Produkt- Nr.
Anmelden zum Anzeigen
Request

Dieses Produkt umsonst

Schicken Sie uns Ihren Validierungsvorschlag. Ich möchte dieses Produkt validieren

Mehr erfahren

Bilder

Spezifität This antibody detects endogenous levels of p40 phox protein. (region surrounding Arg149)
Kreuzreaktivität (Details) Species reactivity (tested):Human, Mouse.
Reinigung The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen
Reinheit > 95 % pure by SDS-PAGE
Andere Bezeichnung NCF-4 (NCF4 Antibody Abstract)
Hintergrund Nicotinamide adenine dinucleotide phosphate (NADPH)-oxidase is a multimeric enzyme system that mediates electron transport from NADPH in the cytoplasm to molecular oxygen in the phagosome, thereby generating reactive oxidant intermediates. Upon neutrophil stimulation, NADPH-oxidase and other cytosolic elements localize to the cell membrane from the cytosol to form a complex which produces phagocytic oxygen radicals. There are a number of cytosolic proteins that are involved in NADPH-oxidase activation/deactivation,including p47-phox, p67-phox, p40-phox and the small GTP-binding protein, Rac. Activation of NADPH oxidase is accompanied by the phosphorylation of cytosolic components p40-phox, p47-phox and p67-phox. The PKC consensus phosphorylation sites Thr 154 and Ser 315 in p40-phox are phosphorylated during activation of NADPH oxidase. p40-phox can promote oxidase activation by increasing the affinity of p47-phox for NADPH-oxidase. However, p40-phox appears to downregulate oxidase function as well, by competing with an SH3 domain interaction between other essential oxidase components.Synonyms: Neutrophil NADPH oxidase factor 4, Neutrophil cytosol factor 4, SH3 and PX domain-containing protein 4, SH3PXD4, p40-phox
Molekulargewicht approx. 39 kDa
Gen-ID 4689
NCBI Accession NP_000622
UniProt Q15080
Applikationshinweise ELISA: 1: 10000approx. 1: 20000. IHC: 1: 50approx. 1: 200.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
Beschränkungen Nur für Forschungszwecke einsetzbar
Konzentration 1,0 mg/mL
Buffer Phosphate buffered saline (PBS), pH 7.2., 0.05 % sodium azide
Konservierungsmittel Sodium azide
Vorsichtsmaßnahmen This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handhabung DO NOT FREEZE!
Lagerung 4 °C
Informationen zur Lagerung Store the antibody undiluted at 2-8 °C.
Bilder des Herstellers
 image for anti-Neutrophil Cytosolic Factor 4, 40kDa (NCF4) Antikörper (ABIN272048) anti-Neutrophil Cytosolic Factor 4, 40kDa (NCF4) antibody