COL3A1 Antikörper (Chain alpha 1)

Produktnummer ABIN272016

Produktdetails anti-COL3A1 Antikörper

Target: COL3A1 (Collagen, Type III, alpha 1 (COL3A1))

Bindungsspezifität: Chain alpha 1

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser COL3A1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)

Spezifität: This antibody detects endogenous levels of Collagen III protein (COL3A1).

Kreuzreaktivität (Details): Species reactivity (expected):Mouse and Rat.
Species reactivity (tested):Human.

Aufreinigung: Affinity Chromatography using epitope-specific immunogen

Anwendungsinformationen

Applikationshinweise: ELISA: 1/10000approx. 1/20000. Immunoflourescence: 1/50approx. 1/200. Immunohistochemistry: 1/50approx. 1/200.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1.0 mg/mL

Buffer: PBS, pH ~7.2, 0.05 % Sodium Azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Referenzen für anti-COL3A1 Antikörper (ABIN272016)

Xie, Dolder, Siegrist, Wetterwald, Hofstetter: "Glutamate Receptor Agonists and Glutamate Transporter Antagonists Regulate Differentiation of Osteoblast Lineage Cells." in: Calcified tissue international, Vol. 99, Issue 2, pp. 142-54, (2018) (PubMed).

Schminke, Frese, Bode, Goldring, Miosge: "Laminins and Nidogens in the Pericellular Matrix of Chondrocytes: Their Role in Osteoarthritis and Chondrogenic Differentiation." in: The American journal of pathology, Vol. 186, Issue 2, pp. 410-8, (2016) (PubMed).

Chen, Yang, Huang, Pan, Liu, Qiu: "Angiotensin-(1-7) attenuates lung fibrosis by way of Mas receptor in acute lung injury." in: The Journal of surgical research, Vol. 185, Issue 2, pp. 740-7, (2013) (PubMed).

Xie, Li, Wang, Zhang, Peng, Yang, Zou, Ge, Chen, Chen: "In vivo delivery of adenoviral vector containing interleukin-17 receptor a reduces cardiac remodeling and improves myocardial function in viral myocarditis leading to dilated cardiomyopathy." in: PLoS ONE, Vol. 8, Issue 8, pp. e72158, (2013) (PubMed).

Zhang, Shen, Zhang, Wan, Yao, Wu, Wang, Chen, Yan, Jiang: "Induction of thoracic aortic remodeling by endothelial-specific deletion of microRNA-21 in mice." in: PLoS ONE, Vol. 8, Issue 3, pp. e59002, (2013) (PubMed).

Details zu COL3A1

Target: COL3A1 (Collagen, Type III, alpha 1 (COL3A1))

Abstract: COL3A1 Produkte

Synonyme: EDS4A antikoerper, AW550625 antikoerper, Col3a-1 antikoerper, MMS10-W antikoerper, Ms10w antikoerper, mKIAA4231 antikoerper, col3a1 antikoerper, collagen type III alpha 1 chain antikoerper, collagen, type III, alpha 1 antikoerper, collagen, type III, alpha 1 (Ehlers-Danlos syndrome type IV, autosomal dominant) S homeolog antikoerper, COL3A1 antikoerper, Col3a1 antikoerper, col3a1 antikoerper, col3a1.S antikoerper

Hintergrund: Collagen III is a fibrillar collagen that is found in extensible connective tissues such as skin, lung, and the vascular system, frequently in association with type I Collagen. Mutations in the gene are associated with Ehlers Danlos syndrome type IV, and with aortic and arterial aneurysms. Although alternate transcripts have been detected for this gene, they are the result of mutations, these mutations alter splicing, often leading to the exclusion of multiple exons.Synonyms: COL3A1

Molekulargewicht: approx. 138 kDa

Gen-ID: 1281

NCBI Accession: NP_000081

UniProt: P02461

Pathways: Autophagie, Growth Factor Binding