CFTR Antikörper

Produktnummer ABIN272010

Produktdetails anti-CFTR Antikörper

Target: CFTR (Cystic Fibrosis Transmembrane Conductance Regulator (ATP-Binding Cassette Sub-Family C, Member 7) (CFTR))

Reaktivität: Human, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser CFTR Antikörper ist unkonjugiert

Applikation: Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Spezifität: This antibody detects endogenous levels of CFTR protein. (region surrounding Glu733)

Kreuzreaktivität (Details): Species reactivity (expected):Mouse and Rat.
Species reactivity (tested):Human.

Aufreinigung: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen

Reinheit: > 95 % pure by SDS-PAGE

Anwendungsinformationen

Applikationshinweise: ELISA: 1: 1000approx. 1: 5000. IHC: 1: 50approx. 1: 200.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1,0 mg/mL

Buffer: Phosphate buffered saline (PBS), pH 7.2., 0.05 % sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: DO NOT FREEZE!

Lagerung: 4 °C

Informationen zur Lagerung: Store the antibody undiluted at 2-8 °C.

Details zu CFTR

Target: CFTR (Cystic Fibrosis Transmembrane Conductance Regulator (ATP-Binding Cassette Sub-Family C, Member 7) (CFTR))

Andere Bezeichnung: ABCC7 / CFTR (CFTR Produkte)

Synonyme: ABC35 antikoerper, ABCC7 antikoerper, CF antikoerper, CFTR/MRP antikoerper, MRP7 antikoerper, TNR-CFTR antikoerper, dJ760C5.1 antikoerper, CFTR antikoerper, AW495489 antikoerper, Abcc7 antikoerper, RGD1561193 antikoerper, abc35 antikoerper, abcc7 antikoerper, cftr/mrp antikoerper, mrp7 antikoerper, tnr-cftr antikoerper, xcftr antikoerper, si:dkey-270i2.2 antikoerper, cystic fibrosis transmembrane conductance regulator antikoerper, cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7) antikoerper, CFTR antikoerper, cftr-A antikoerper, Cftr antikoerper, cftr antikoerper

Hintergrund: CFTR, for cystic fibrosis transmembrane conductance regulator, is a cyclic adenosine monophosphate (cAMP)-regulated chloride channel protein. CFTR belongs to the MDR subfamily within the ATP-binding transport protein family. It has two transmembrane domains (TMDs), two nucleotide binding domains (NBDs) and one regulatory domain. Mutations of CFTR are associated with cystic fibrosis (CF), a disease characterized by chronic bronchopulmonary disease, elevated sweat electrolytes and insufficient pancreatic function. CFTR mutations can also result in congenital bilateral absence of vas deferens (CBAVD), a form of male sterility that a majority of male CF patients exhibit. Since the CF mutation is lethal, most often by lung and liver disease, it raises the question of why this genetic disease remains as common as it is. One possible explanation is that Salmonella typhi has been shown to use CFTR to enter intestinal epithelial cells and that delta F508 heterozygote and homozygote mice showed 86 % and 100 % reductions in S. typhi intestinal submucosal uptake.Synonyms: ATP-binding cassette transporter sub-family C member 7, Channel conductance-controlling ATPase, Cystic fibrosis transmembrane conductance regulator, cAMP-dependent chloride channel

Molekulargewicht: approx. 168 kDa

Gen-ID: 1080

NCBI Accession: NP_000483

UniProt: P13569