Cyclin L1 Antikörper

Produktnummer ABIN271776

Produktdetails anti-Cyclin L1 Antikörper

Target: Cyclin L1 (CCNL1)

Reaktivität: Human, Ratte, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Cyclin L1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Spezifität: This antibody detects endogenous levels of Cyclin-L1 protein. (region surrounding Glu491)

Kreuzreaktivität (Details): Species reactivity (expected):Mouse and Rat.
Species reactivity (tested):Human.

Aufreinigung: Affinity Chromatography using epitope-specific immunogen

Anwendungsinformationen

Applikationshinweise: ELISA: 1: 10000approx. 1: 20000. WB: 1: 500approx. 1: 1000. IHC: 1: 50approx. 1: 200.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1.0 mg/mL

Buffer: Phosphate buffered saline (PBS), pH ~7.2, 0.05 % Sodium Azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Details zu Cyclin L1

Target: Cyclin L1 (CCNL1)

Andere Bezeichnung: Cyclin L1 (CCNL1 Produkte)

Synonyme: ANIA6A antikoerper, PRO1073 antikoerper, ania-6a antikoerper, 2610030E23Rik antikoerper, AU018493 antikoerper, Ccnl antikoerper, Ania-6a antikoerper, ccnl1 antikoerper, fd99b09 antikoerper, wu:fd99b09 antikoerper, zgc:55544 antikoerper, MCM2 antikoerper, cyclin-L1 antikoerper, MGC132032 antikoerper, bm-001 antikoerper, pro1073 antikoerper, MGC108436 antikoerper, Ccnl1 antikoerper, cyclin L1 antikoerper, cyclin L1b antikoerper, cyclin-L1 antikoerper, cyclin L1 L homeolog antikoerper, cyclin L1 S homeolog antikoerper, CCNL1 antikoerper, Ccnl1 antikoerper, ccnl1b antikoerper, LOC485730 antikoerper, ccnl1.L antikoerper, ccnl1 antikoerper, LOC100136245 antikoerper, ccnl1.S antikoerper

Hintergrund: Cell proliferation is controlled at specific stages of the cell cycle by distinct protein kinase complexes. These complexes consist of a catalytic subunit associating with a specific regulatory subunit to form the active kinase. The cyclins, which include cyclin A, B, C, D, E, F, G, H, I, K, L, T and their related proteins, including Dbf4, comprise the regulatory subunits of these kinase complexes. The controlled activation of the kinase complexes at various intervals of the cell cycle is regulated by the availability of the cyclins to the catalytic subunit. Unlike the catalytic subunit, which is expressed continually, the expression and stability of the regulatory subunit fluctuates depending on the stage of the cell cycle and, thereby, regulates the kinase activity. Cyclin L1 is a ubiquitously expressed nuclear protein that can be detected in higher levels in thymus. In neck and head squamous cell carcinomas, cyclin L1 can be overexpressed and is therefore often considered a proto-oncogene. It interacts with POLR2A, CDC2L and SFRS2. Cyclin L1 plays a role in the mRNA splicing process regulation.Synonyms: BM-001, CCNL1, Cyclin-L, Cyclin-L1

Molekulargewicht: approx. 60 kDa

Gen-ID: 57018

NCBI Accession: NP_064703

UniProt: Q9UK58