Chemokine (C-C Motif) Receptor 7 (CCR7) Antikörper

Antigen: Chemokine (C-C Motif) Receptor 7 (CCR7)

Synonyme: BLR2, EBI1, CD197, CDw197, CMKBR7, Ebi1h, Cdw197, Cmkbr7, MGC108519, CCR7, MGC165629, zgc:165629

Klonalität: Polyklonal

Wirt: Kaninchen

Reaktivität: Human

Applikation: Immunhistochemie (Gefrierschnitte) (IHC (fro)), Immunfluoreszenz (IF), Immunhistochemie (Paraffinschnitte) (IHC (p))

Produktnummer: ABIN271333

Produktbeschreibung

Weitere Bezeichnung: CD197 / CCR7

Gen-ID: 1236

Immunogen: Synthetic peptide [KLH conjugated] made to the C-term.

Beschreibung: CCR7, a Chemokine Receptor, is involved in lymphocyte recirculation throughsecondary lymphoid organs and moving lymphocytes and dendritic cells into distincttissue compartments. CCR7 is called the Epstein-Barr-induced receptor because itmediates Epstein-Barr viral effects on B lymphocytes. CCR7 expression is up-regulatedin mature dendritic cells, B cells infected with EBV, and in CD4+ cells infected withhuman herpes virus 6 and 7. Immature dendritic cells have been shown to expresschemokine receptor 5 (CCR5) and migrate in response to macrophage inflammatoryprotein-1alpha (MIP-1alpha), whereas mature dendritic cells switch to CCR7 expressionand respond exclusively to MIP-3beta and 6Ckine. Maturing dendritic cells upregulateCCR7, which drives their migration to the T-cell areas of the draining lymph nodeswhere antigen is presented to naive T cells. CCR7 has been reported to be expressedin blood, bone marrow, lymph node, and intestine. This receptor is particularlyexpressed in lymphoid tissues and in activated B and T lymphocytes. ESTs have beenisolated from blood, embryo, lymph node, and thymus libraries.

Spezifität: Species Reactivity: Human. There is 94 % rat identity and 100 % rat homology. There is 84 % mouseidentity and 89 % mouse homology.

Anwendungen

Konzentration: 1 mg/ml

Buffer: Phosphate buffered saline, PH 7.7. Preservative: 0.01% Sodium Azide.

Lagerung: Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze thaw cycles.

Forschungsgebiet: CD Antigene, Oberflächenrezeptoren der Immunzellen

Beschränkungen: Nur für Forschungszwecke einsetzbar