Chemokine (C-C Motif) Receptor 2 (CCR2) Antikörper

Antigen: Chemokine (C-C Motif) Receptor 2 (CCR2)

Synonyme: Ckr2, Ccr2a, Ccr2b, Ckr2a, Ckr2b, mJe-r, Cmkbr2, Cc-ckr-2, CKR2, CCR2A, CCR2B, CD192, CKR2A, CKR2B, CMKBR2, MCP-1-R, CC-CKR-2, FLJ78302, MGC103828, MGC111760, MGC168006

Klonalität: Polyklonal

Wirt: Kaninchen

Reaktivität: Human

Applikation: Immunhistochemie (Paraffinschnitte) (IHC (p))

Produktnummer: ABIN270725

Produktbeschreibung

Weitere Bezeichnung: CD192 / CCR2

Gen-ID: 1231

Immunogen: Synthetic peptide [KLH conjugated] made to the N-term extracellular.

Beschreibung: CCR2, a Chemokine Receptor, is a regulator of monocyte/macrophage traffickingis andis upregulated in response to inflammation. Resistance to HIV-1 infection or delayedprogression to AIDS may be linked to CCR2 polymorphisms. The ligand for CCR2 ismonocyte chemoattractant protein (MCP-1), a chemokine produced by endothelial cells,smooth muscle cells, and macrophages. Activation of monocytes by MCP-1 maymediate the monocytic infiltration of tissues in atherosclerosis (Boring et al., 1998) andother inflammatory disorders including rheumatoid arthritis, alveolitis, and tumorinfiltration. Two isoforms are produced by alternative splicing. CCR2 has been reportedto be expressed in a wide variety of tissues, including blood, brain, heart, kidney, liver,lung, ovary, pancreas, spinal cord, spleen, thymus, and vessel. Increased expressionof CCR2 has been documented in CD3+ lymphocytes in rheumatoid arthritis (Ruth et al.,2001). ESTs have been isolated from liver/spleen and prostate libraries. Alternate Names: anti-CC chemokine receptor type 2 antibody, anti-CCCKR2 antibody, anti-CCR1Lantibody, anti-CCR2A antibody, anti-CCR2B antibody, anti-CCR5L antibody,anti-CD192 antigen antibody, anti-Chemokine CC Motif Receptor 2 antibody,anti-CMKBR2 antibody, anti-MCP1R antibody, anti-Monocyte chemoattractant protein 1receptor antibody, anti-Monocyte Chemotactic Protein 1 Receptor antibody.

Spezifität: Species Reactivity: Human. Localization: Membrane, multi pass membrane protein.

Anwendungen

Konzentration: 1 mg/ml

Buffer: PBS, pH 7.7. Preservative: 0.01% sodium azide.

Lagerung: Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze thaw cycles.

Forschungsgebiet: Chemokine, Rezeptoren

Beschränkungen: Nur für Forschungszwecke einsetzbar