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Antikörper
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anti-BMI1 Polycomb Ring Finger Oncogene (BMI1) Antikörper
BMI1 Polycomb Ring Finger Oncogene (BMI1) Antikörper
| Antigen |
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| Synonyme |
PCGF4, RNF51, MGC12685, Bmi-1, Pcgf4, AW546694, psc1, pcgf4, wu:fb17g03, wu:fd18f06, BMI1, MGC134151 |
| Klonalität |
Polyklonal |
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Wirt
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Reaktivität
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Applikation
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 Alternativen Enzyme Immunoassay (EIA), Immunfluoreszenz (IF), Western Blot (WB)
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| Produktnummer |
ABIN269746 |
| Menge |
0.1 mg (0.91 mg/ml) |
| Preis |
430,00 € Zzgl. Versandkosten €20,00 und MWSt
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| Lieferung nach |
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| Verfügbarkeit |
Lieferung in 7 bis 10 Werktagen |
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Weitere Bezeichnung
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BMI-1 / RNF51
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Gen-ID
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648, 12151, 307151
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Immunogen
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Synthetic peptide: CDSGSDKANSPAGG, corresponding to amino acids 252-264 ofHuman Bmi1.
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Isotyp
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IgG (Passende Sekundärantikörper)
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Beschreibung
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The Bmi1 oncogene induces telomerase activity and immortalizes human mammaryepithelial cells. Bmi1 extends the replicative life span of human fibroblasts bysuppressing the p16-dependent senescence pathway. Polycomb group (PcG) genesare involved in the maintenance of cellular memory through epigenetic chromatinmodifications. Recent studies have implicated a role for PcG genes in the self-renewalof hematopoietic stem cells (HSCs), a process in which cellular memory is maintainedthrough cell division. Among the PcG genes, Bmi1 plays a central role in the inheritanceof stemness, and its forced expression promotes HSC self-renewal. These findingshighlight the importance of epigenetic regulation in HSC self-renewal and identify PcGgenes as potential targets for therapeutic HSC manipulation. Involved in maintaining thetranscriptionally repressive state of genes. Modifies chromatin, rendering it heritablychanged in its expressibility. Alternate Names: anti-MGC12685 antibody, anti-Murine leukemia viral (bmi 1) oncogene homologantibody, anti-Oncogene BMI 1 antibody, anti-PCGF4 antibody, anti-Polycomb complex protein BMI 1 antibody, anti-Polycomb complex protein BMI-1antibody, anti-Polycomb group ring finger 4 antibody, anti-RING finger protein 51 antibody, anti-RING finger protein 51 antibody, anti-RNF51antibody.
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Spezifität
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Species Reactivity: Reacts with Human. Predicted to react with Mouse, Rat, Cat and Dog (all show 100%identity with immunogen) due to sequence homology. Not yet tested in other species. Localization: Nuclear.
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Applikationshinweise
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Suggested working dilutions: ELISA 1/5000 - 1/30000 ,Western Blot 1/500 - 1/3000
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Konzentration
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0.91 mg/ml
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Buffer
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0.15M Sodium chloride, 0.02M Potassium phosphate
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Lagerung
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Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze thaw cycles.
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Beschränkungen
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Nur für Forschungszwecke einsetzbar
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Alternativen zu Antigen "BMI1 Polycomb Ring Finger Oncogene (BMI1)", Typ "Antikörper" finden
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Wirte
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Kaninchen (25), Ziege (5), Maus (3)
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Reaktivitäten
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Human (32), Maus (19), Ratte (Rattus) (9), Katze (4), Huhn (4), Rind (Kuh) (4), Affe (4), Hund (3), Frosch (1), Kaninchen (1)
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Applikationen
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Western Blot (WB) (30), Enzyme Immunoassay (EIA) (9), Immunhistochemie (Paraffinschnitte) (IHC (p)) (8), ELISA (5), Immunfluoreszenz (IF) (4), Immunpräzipitation (IP) (2), ELISA (Detektionsantikörper) (1), Immunhistochemie (IHC) (1)
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Konjugate
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Biotin (1), HRP (1)
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Epitope
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C-Term (2), AA 252-264 (1), Center (1)
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