Tubulin, Beta, 3 (TUBB3) Antikörper (FITC)

Antigen: Tubulin, Beta, 3 (TUBB3)

Synonyme: TUBB3, TUBB4, MGC134115, MC1R, beta-4, tbb3, M(beta)3, M(beta)6, 3200002H15Rik, tubb3, MGC76202, TUBB1, tubB3, tubulin

Klonalität: Monoklonal (TU-20)

Wirt: Maus

Reaktivität: Diverse Spezies

Konjugat: FITC

Applikation: Immunfluoreszenz (IF)

Produktnummer: ABIN269248

Produktbeschreibung

Weitere Bezeichnung: TUBB3 / TUBB4

Gen-ID: 10381

Immunogen: Synthetic peptide: corresponding to amino acids (C)441-448 (ESESQGPK) of beta IIITubulin conjugated to maleimide activated KLH via cysteine added to the N terminus ofthe neurone specific peptide.

Isotyp: IgG1

Klon: TU-20

Beschreibung: Tubulin is the major building block of microtubules. This intracellular cylindricalfilamentous structure is present in almost all eukaryotic cells. Microtubules function asstructural and mobile elements in mitosis, intracellular transport, flagellar movement,and the cytoskeleton. Except in the simplest eukaryotes, tubulin exists in all cells as amixture of similar, but not identical, sets of alpha and beta tubulin polypeptides. Withineither set of polypeptides, individual subunits diverge from each other (both within andacross species) at less than 10% of the amino acid positions. The most extremediversity is localized to the 15 residues of the carboxy terminal. For beta tubulin fiveevolutionarily conserved isotype clones have been identified. These are almost totallyconserved in the subunits utilized in the same cell types of different species, with theexception of the hematopoietic beta tubulin which is the most highly divergent insequence and is not conserved between species. Research has been centered aroundthe hypothesis that these beta tubulin isotypes contribute to unique functionalproperties. It has been reported that the different isotypes of tubulin differ from eachother in their ability to polymerize into microtubules. The monoclonal antibody fromhybridoma SDL.3D10 can stimulate microtubule assembly when reconstituted withtubulin, tau or MAP2. Alternate Names: anti-M(beta)3 antibody, anti-M(beta)6 antibody, anti-MC1R antibody, anti-TUBB4antibody, anti-Tubulin beta 3 antibody, anti-Tubulin beta 4 antibody.

Spezifität: This antibody recognizes the peptide sequence ESESQGPK (amino acids 441-448) ofhuman class III beta tubulin specific for neurones. Species Reactivity: All (the recognized epitope is conserved within all species).

Anwendungen

Applikationshinweise: Suggested working dilutions: Immunocytochemistry 1/40

Konzentration: 1 mg/ml

Buffer: PBS. pH 7.4. Preservative: Sodium Azide.

Lagerung: Store at 4C. Do not freeze.

Beschränkungen: Nur für Forschungszwecke einsetzbar