CRLF2 Antikörper

Produktnummer ABIN2689945

Produktdetails anti-CRLF2 Antikörper

Target: CRLF2 (Cytokine Receptor-Like Factor 2 (CRLF2))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser CRLF2 Antikörper ist unkonjugiert

Applikation: Flow Cytometry (FACS), Neutralization (Neut)

Marke: BD Pharmingen™

Produktmerkmale: The 1F11/TSLPR monoclonal antibody specifically binds to Thymic Stromal Lymphopoietin Receptor (TSLPR). TSLPR is a member of the hematopoietin receptor superfamily and is also known as Cytokine Receptor-like Factor 2 (CRL2, CRLF2Y, CRLF2). The functional TSLPR complex consists of two subunits, TSLPR and the alpha subunit of the Interleukin-7 Receptor (IL-7Rα). Analysis of the TSLPR reveals sequence similarity with the common cytokine receptor gamma chain (γc, CD132). Functional TSLPRs are expressed by epithelial cells and a variety of hematopoietic cell types, including thymocytes, T cells, B cells, natural killer T cells, monocytes, macrophages, basophils, and dendritic cells (DC). Recent studies indicate that TSLP can activate multiple STAT (Signal Transducer and Activator of Transcription) signaling proteins. TSLP enhances the maturation and viability of DC. It strongly induces DC expression of the CD40 and CD80 costimulatory molecules and chemokines, e.g., TARC (Thymus and activation-regulated chemokine, CCL17) that can attract Th2 effector cells. TSLP supports B cell development. TSLP costimulates the proliferation of naive T cells in the presence of mature DC. TSLP is also able to increase the sensitivity of T cell receptor-activated CD4+ T cells to low doses of IL-2. In the presence of TSLP, the acute myeloid leukemia-derived cell line, MUTZ-3, shows induced growth and reduced apoptosis. CRLF2 deregulated gene expression is thought to be involved in lymphoid transformation in B-cell precursor acute lymphoblastic leukemia. The 1F11/TSLPR antibody is reportedly a neutralizing antibody.

BD Pharmingen™ Purified NA/LE Mouse Anti-Human TSLP Receptor - NA/LE - Clone 1F11/TSLPR (also known as 1F11 and AB81_85.1F11) - Isotype Mouse IgG1, κ - Reactivity Hu - 100 μg

Aufreinigung: The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.

Immunogen: Human TSLP Receptor Transfected Cell Line

Klon: 1F11-TSLPR

Isotyp: IgG1 kappa

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1.0 mg/mL

Buffer: Aqueous buffered solution containing no preservative.

Konservierungsmittel: Without preservative

Handhabung: This preparation contains no preservatives, thus it should be handled under aseptic conditions.

Lagerung: 4 °C

Informationen zur Lagerung: Store undiluted at 4°C.

Referenzen für anti-CRLF2 Antikörper (ABIN2689945)

Ito, Liu, Arima: "Cellular and molecular mechanisms of TSLP function in human allergic disorders--TSLP programs the "Th2 code" in dendritic cells." in: Allergology international : official journal of the Japanese Society of Allergology, Vol. 61, Issue 1, pp. 35-43, (2012) (PubMed).

Ziegler: "Thymic stromal lymphopoietin and allergic disease." in: The Journal of allergy and clinical immunology, Vol. 130, Issue 4, pp. 845-52, (2012) (PubMed).

Pedroza-Gonzalez, Xu, Wu, Aspord, Tindle, Marches, Gallegos, Burton, Savino, Hori, Tanaka, Zurawski, Zurawski, Bover, Liu, Banchereau, Palucka: "Thymic stromal lymphopoietin fosters human breast tumor growth by promoting type 2 inflammation." in: The Journal of experimental medicine, Vol. 208, Issue 3, pp. 479-90, (2011) (PubMed).

Arima, Watanabe, Hanabuchi, Chang, Sun, Liu: "Distinct signal codes generate dendritic cell functional plasticity." in: Science signaling, Vol. 3, Issue 105, pp. ra4, (2010) (PubMed).

Lu, Wang, Wang, Arima, Hanabuchi, Liu: "TSLP and IL-7 use two different mechanisms to regulate human CD4+ T cell homeostasis." in: The Journal of experimental medicine, Vol. 206, Issue 10, pp. 2111-9, (2009) (PubMed).

Russell, Capasso, Vater, Akasaka, Bernard, Calasanz, Chandrasekaran, Chapiro, Gesk, Griffiths, Guttery, Haferlach, Harder, Heidenreich, Irving, Kearney, Nguyen-Khac, Machado, Minto, Majid, Moorman et al.: "Deregulated expression of cytokine receptor gene, CRLF2, is involved in lymphoid transformation in B-cell precursor acute lymphoblastic leukemia. ..." in: Blood, Vol. 114, Issue 13, pp. 2688-98, (2009) (PubMed).

Rochman, Watanabe, Arima, Liu, Leonard: "Cutting edge: direct action of thymic stromal lymphopoietin on activated human CD4+ T cells." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 178, Issue 11, pp. 6720-4, (2007) (PubMed).

Tedla, Bandeira-Melo, Tassinari, Sloane, Samplaski, Cosman, Borges, Weller, Arm: "Activation of human eosinophils through leukocyte immunoglobulin-like receptor 7." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 100, Issue 3, pp. 1174-9, (2003) (PubMed).

Quentmeier, Drexler, Fleckenstein, Zaborski, Armstrong, Sims, Lyman: "Cloning of human thymic stromal lymphopoietin (TSLP) and signaling mechanisms leading to proliferation." in: Leukemia, Vol. 15, Issue 8, pp. 1286-92, (2001) (PubMed).

Details zu CRLF2

Target: CRLF2 (Cytokine Receptor-Like Factor 2 (CRLF2))

Andere Bezeichnung: TSLP Receptor (CRLF2 Produkte)

Synonyme: CRLF2 antikoerper, CRL2 antikoerper, CRLF2Y antikoerper, TSLPR antikoerper, CRLM2 antikoerper, Ly114 antikoerper, Tpte2 antikoerper, Tslpr antikoerper, Crl2 antikoerper, cytokine receptor like factor 2 antikoerper, cytokine receptor-like factor 2 antikoerper, CRLF2 antikoerper, Crlf2 antikoerper

Hintergrund: Synonyms: CRL2, CRLF2, CRLF2Y, Cytokine receptor-like factor 2, IL-XR, TSLPR