Telefon:
+49 (0)241 95 163 153
Fax:
+49 (0)241 95 163 155
E-Mail:
orders@antikoerper-online.de

MADCAM1 Antikörper

MADCAM1 Reaktivität: Maus FACS, IHC (fro), IHC (f) Wirt: Ratte Monoclonal MECA unconjugated
Produktnummer ABIN2689830
  • Target Alle MADCAM1 Antikörper anzeigen
    MADCAM1 (Mucosal Vascular Addressin Cell Adhesion Molecule 1 (MADCAM1))
    Reaktivität
    • 45
    • 45
    • 7
    • 1
    Maus
    Wirt
    • 47
    • 15
    • 6
    Ratte
    Klonalität
    • 47
    • 21
    Monoklonal
    Konjugat
    • 25
    • 6
    • 6
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser MADCAM1 Antikörper ist unkonjugiert
    Applikation
    • 57
    • 34
    • 26
    • 26
    • 16
    • 13
    • 10
    • 6
    • 4
    • 4
    • 3
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    Flow Cytometry (FACS), Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunohistochemistry (Formalin-fixed Sections) (IHC (f))
    Marke
    BD Pharmingen™
    Produktmerkmale
    The MECA-367 antibody reacts with mucosal vascular addressin MAdCAM-1. In the fetus and neonate, MAdCAM-1 is the predominant vascular addressin on the high endothelial venules (HEV) of peripheral lymph nodes. In adult mice, MAdCAM-1 is preferentially expressed in mucosal lymphoid tissues and lamina propria, it is also expressed on sinus-lining cells in the spleen. MAdCAM-1 expression is upregulated on the HEV of peripheral lymph nodes in adult NOD mice4 and is involved in the development of diabetes and insulitis. Furthermore, there is evidence that IFN-γ can induce MAdCAM-1 expression in non-mucosal sites in adult mice. MAdCAM-1 is a predominant ligand for integrin α4β7, a lymphocyte mucosal homing receptor, and a facultative ligand for CD62L (L-selectin). MECA-367 mAb binds to the first domain of MAdCAM-1 and blocks MAdCAM-1-dependent binding in vitro and lymphocyte homing to Peyer's patch HEV in vivo. Source of the immunogen was endothelial cells from BALB/c mouse mesenteric and peripheral lymph nodes. Immunohistochemical staining of mouse MadCAM-1: Frozen sections of normal mouse small intestine were reacted with the anti-MadCAM-1 antibody. Cells of the lamina propria and the mucosal lymphoid tissue expressing MadCAM-1 can be identified by the brown labeling of their cell membranes. Amplification 20X.

    BD Pharmingen™ Purified Rat Anti-Mouse MAdCAM-1 - Purified - Clone MECA-367 - Isotype Rat IgG2a, κ - Reactivity Ms - 1 mL
    Aufreinigung
    The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
    Immunogen
    Mouse endothelial cells from BALB/c mouse mesenteric and peripheral lymph nodes.
    Klon
    MECA
    Isotyp
    IgG2a kappa
    Top Product
    Discover our top product MADCAM1 Primärantikörper
  • Applikationshinweise
    Optimal working dilution should be determined by the investigator.
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    31.25 μg/mL
    Buffer
    Aqueous buffered solution containing BSA, goat serum, and ≤0.09 % sodium azide.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    4 °C
    Informationen zur Lagerung
    Store undiluted at 4°C.
  • Berg, McEvoy, Berlin, Bargatze, Butcher: "L-selectin-mediated lymphocyte rolling on MAdCAM-1." in: Nature, Vol. 366, Issue 6456, pp. 695-8, (1994) (PubMed).

    Berlin, Berg, Briskin, Andrew, Kilshaw, Holzmann, Weissman, Hamann, Butcher: "Alpha 4 beta 7 integrin mediates lymphocyte binding to the mucosal vascular addressin MAdCAM-1." in: Cell, Vol. 74, Issue 1, pp. 185-95, (1993) (PubMed).

    Briskin, McEvoy, Butcher: "MAdCAM-1 has homology to immunoglobulin and mucin-like adhesion receptors and to IgA1." in: Nature, Vol. 363, Issue 6428, pp. 461-4, (1993) (PubMed).

    Streeter, Berg, Rouse, Bargatze, Butcher: "A tissue-specific endothelial cell molecule involved in lymphocyte homing." in: Nature, Vol. 331, Issue 6151, pp. 41-6, (1988) (PubMed).

  • Target
    MADCAM1 (Mucosal Vascular Addressin Cell Adhesion Molecule 1 (MADCAM1))
    Andere Bezeichnung
    MAdCAM-1 (MADCAM1 Produkte)
    Synonyme
    MACAM1 antikoerper, AV211525 antikoerper, mucosal vascular addressin cell adhesion molecule 1 antikoerper, MADCAM1 antikoerper, Madcam1 antikoerper
Sie sind hier:
Kundenservice