LAIR1 Antikörper

Produktnummer ABIN2689802

Produktdetails anti-LAIR1 Antikörper

Target: LAIR1 (Leukocyte-Associated Immunoglobulin-Like Receptor 1 (LAIR1))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser LAIR1 Antikörper ist unkonjugiert

Applikation: Flow Cytometry (FACS)

Marke: BD Pharmingen™

Produktmerkmale: eacts with leukocyte associated immunoglobulin-like receptor-1 (LAIR-1), a 32 kDa transmembrane glycoprotein with a single immunoglobulin-like domain and a cytoplasmic tail containing two immune receptor tyrosine-based inhibitory motifs. It is expressed on the majority of human peripheral blood mononuclear leukocytes. LAIR-1 recruits SHP-1 and SHP-2 tyrosine phosphatases upon activation, and cross-linking of the LAIR-1 Molecule on NK cells results in strong inhibition of NK cell-mediated cytotoxicity. Although it is structurally related to human killer cell inhibitory receptors, LAIR-1 does not appear to recognize MHC class I molecules and thus represents a novel MHC class I-independent mechanism of NK cell regulation. Other studies report other roles of LAIR-1 in cell differentiation. Profile of peripheral blood lymphocytes analyzed by flow cytometry

BD Pharmingen™ Purified Mouse Anti-Human LAIR-1 - Purified - Clone DX26 - Isotype Mouse IgG1, κ - Reactivity Hu - 0.1 mg

Aufreinigung: The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.

Klon: DX26

Isotyp: IgG1 kappa

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 0.5 mg/mL

Buffer: Aqueous buffered solution containing ≤0.09 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C

Informationen zur Lagerung: Store undiluted at 4°C.

Referenzen für anti-LAIR1 Antikörper (ABIN2689802)

Xu, Zhao, Zhao: "Identification and characterization of leukocyte-associated Ig-like receptor-1 as a major anchor protein of tyrosine phosphatase SHP-1 in hematopoietic cells." in: The Journal of biological chemistry, Vol. 275, Issue 23, pp. 17440-6, (2000) (PubMed).

Meyaard, Adema, Chang, Woollatt, Sutherland, Lanier, Phillips: "LAIR-1, a novel inhibitory receptor expressed on human mononuclear leukocytes." in: Immunity, Vol. 7, Issue 2, pp. 283-90, (1997) (PubMed).

Details zu LAIR1

Target: LAIR1 (Leukocyte-Associated Immunoglobulin-Like Receptor 1 (LAIR1))

Andere Bezeichnung: LAIR-1 (LAIR1 Produkte)

Synonyme: 5133400O11Rik antikoerper, BB115266 antikoerper, D7Bwg0421e antikoerper, Lair-1 antikoerper, mLair-1 antikoerper, CD305 antikoerper, LAIR-1 antikoerper, leukocyte-associated Ig-like receptor 1 antikoerper, leukocyte associated immunoglobulin like receptor 1 antikoerper, leukocyte-associated immunoglobulin-like receptor 1 antikoerper, Lair1 antikoerper, LAIR1 antikoerper