Tumor Necrosis Factor (Ligand) Superfamily, Member 18 (TNFSF18) Antikörper

Details zu Produkt Nr. ABIN2689521, Anbieter: Anmelden zum Anzeigen
Antigen
  • Gitrl
  • AITRL
  • GITRL
  • TL6
  • hGITRL
  • TNLG2A
  • tumor necrosis factor (ligand) superfamily, member 18
  • TNF superfamily member 18
  • Tnfsf18
  • TNFSF18
Reaktivität
Maus
146
63
18
2
2
1
Wirt
Ratte
77
73
33
2
Klonalität (Klon)
Monoklonal ()
Konjugat
Unkonjugiert
10
8
7
6
5
5
5
5
5
5
4
4
4
3
3
2
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Applikation
Flow Cytometry (FACS)
90
87
79
13
7
6
5
4
4
4
4
4
2
2
2
1
1
1
Optionen
Hersteller
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Hersteller Produkt- Nr.
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Marke BD Pharmingen™
Immunogen GITRL/GFP-transfected L cells
Klon MIH44
Isotyp IgG2b, kappa
Produktmerkmale The MIH44 monoclonal antibody specifically binds to Glucocorticoid-induced TNF-related Ligand (GITR Ligand). The GITR Ligand protein is encoded by the Tnfsf18 (Tumor necrosis factor ligand superfamily member 18) gene. The GITR Ligand is a type II transmembrane protein that is expressed on endothelial cells and antigen presenting cells, including B cells, macrophage and dendritic cells. The GITR Ligand reportedly costimulates T cell activation and reverses CD4+CD25+ Treg cell-mediated suppression by interaction with its cognate receptor, GITR that is expressed by these cells. Flow cytometric analysis of mouse GITR Ligand expression on non-transfected and GITR Ligand-transfected cells. Non-transfected (Left Panel) and GITR Ligand-transfected (Right Panel) P815 cells were surface stained with either Purified Rat IgG2b, κ Isotype Control (Cat. No. 553986) or Purified Rat Anti-Mouse GITR Ligand (Cat. No. 562238) followed by staining with PE Goat Anti-Rat Ig (Cat. No. 550767). Flow cytometric fluorescence histograms showing the expression of GITR Ligand (solid line histograms) or Ig Isotype Control staining (dotted line histograms) on non-transfected or GITR Ligand-transfected P815 cells were derived from gated events with the forward and side light-scatter characteristics of viable cells. Flow cytometric analyses were performed using a BD™ LSR II Flow Cytometer System.

BD Pharmingen™ Purified Rat anti-Mouse GITR Ligand - Purified - Clone MIH44 - Isotype Rat IgG2b, κ - Reactivity Ms - 0.1 mg
Reinigung The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
Andere Bezeichnung GITR Ligand (TNFSF18 Antibody Abstract)
Hintergrund Synonyms: Tnfsf18, Gitrl,Glucocorticoid-induced-tumor necrosis factor receptor ligand Entrez Gene ID: 240873
Forschungsgebiet Growth Factors
Applikationshinweise Optimal working dilution should be determined by the investigator.
Beschränkungen Nur für Forschungszwecke einsetzbar
Konzentration 0.5 mg/mL
Buffer Aqueous buffered solution containing ≤0.09 % sodium azide.
Konservierungsmittel Sodium azide
Vorsichtsmaßnahmen This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Lagerung 4 °C
Informationen zur Lagerung Store undiluted at 4°C.
Produkt verwendet in: Piao, Kamimura, Iwai, Cao, Kikuchi, Hashiguchi, Masunaga, Jiang, Tamura, Sakaguchi, Azuma: "Enhancement of T-cell-mediated anti-tumour immunity via the ectopically expressed glucocorticoid-induced tumour necrosis factor receptor-related receptor ligand (GITRL) on tumours." in: Immunology, Vol. 127, Issue 4, pp. 489-99, 2009 (PubMed).

Igarashi, Cao, Iwai, Piao, Kamimura, Hashiguchi, Amagasa, Azuma: "GITR ligand-costimulation activates effector and regulatory functions of CD4+ T cells." in: Biochemical and biophysical research communications, Vol. 369, Issue 4, pp. 1134-8, 2008 (PubMed).

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