FCGR1A Antikörper (Biotin)

Produktnummer ABIN2689372

Produktdetails anti-FCGR1A Antikörper (Biotin)

Target: FCGR1A (Fc Fragment of IgG, High Affinity Ia, Receptor (CD64) (FCGR1A))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser FCGR1A Antikörper ist konjugiert mit Biotin

Applikation: Flow Cytometry (FACS)

Marke: BD Pharmingen™

Produktmerkmale: The monoclonal antibody 10.1 reacts with CD64, a 75 kD type I transmembrane glycoprotein that is a high affinity receptor for IgG (FcγRI). CD64, a key receptor in the development of immune responses, has a dual role as a low affinity receptor for IgG3 and high affinity receptor for IgG2a linking innate and adaptive immunities. CD64 mediates endocytosis, phagocytosis, antibody-dependent cellular toxicity, cytokine release and superoxide generation. CD64 is expressed largely on macrophages and dendritic cells. This antibody is routinely tested by flow cytometric analysis. Other applications were tested during antibody development only or reported in the literature. Profile of peripheral blood monocytes analyzed on a FACScan

BD Pharmingen™ Biotin Mouse Anti-Human CD64 - Biotin - Clone 10.1 - Isotype Mouse IgG1, κ - Reactivity Hu - 100 Tests

Aufreinigung: The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.

Klon: 10-1

Isotyp: IgG1 kappa

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Probenmenge: 20 μL

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Buffer: Aqueous buffered solution containing BSA and ≤0.09 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: The antibody was conjugated with biotin under optimum conditions, and unreacted biotin was removed.

Lagerung: 4 °C

Informationen zur Lagerung: Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.

Referenzen für anti-FCGR1A Antikörper (Biotin) (ABIN2689372)

Indik, Hunter, Huang, Pan, Chien, Kelly, Levinson, Kimberly, Schreiber: "The high affinity Fc gamma receptor (CD64) induces phagocytosis in the absence of its cytoplasmic domain: the gamma subunit of Fc gamma RIIIA imparts phagocytic function to Fc gamma RI." in: Experimental hematology, Vol. 22, Issue 7, pp. 599-606, (1994) (PubMed).

Dougherty, Selvendran, Murdoch, Palmer, Hogg: "The human mononuclear phagocyte high-affinity Fc receptor, FcRI, defined by a monoclonal antibody, 10.1." in: European journal of immunology, Vol. 17, Issue 10, pp. 1453-9, (1987) (PubMed).

Guesdon, Ternynck, Avrameas: "The use of avidin-biotin interaction in immunoenzymatic techniques." in: The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society, Vol. 27, Issue 8, pp. 1131-9, (1979) (PubMed).

Details zu FCGR1A

Target: FCGR1A (Fc Fragment of IgG, High Affinity Ia, Receptor (CD64) (FCGR1A))

Andere Bezeichnung: CD64 (FCGR1A Produkte)

Synonyme: CD64 antikoerper, CD64A antikoerper, FCRI antikoerper, IGFR1 antikoerper, FcgammaRI antikoerper, Fcgr1 antikoerper, Fcgr1b antikoerper, AI323638 antikoerper, AV092959 antikoerper, IGGHAFC antikoerper, FCGR1A antikoerper, Fc fragment of IgG receptor Ia antikoerper, Fc receptor, IgG, high affinity I antikoerper, FCGR1A antikoerper, Fcgr1a antikoerper, Fcgr1 antikoerper

Pathways: Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process