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Prostaglandin D2 Receptor 2 (PTGDR2) Antikörper

PTGDR2 Reaktivität: Human FACS Wirt: Ratte Monoclonal BM16 unconjugated
Produktnummer ABIN2689160
  • Target Alle Prostaglandin D2 Receptor 2 (PTGDR2) Antikörper anzeigen
    Prostaglandin D2 Receptor 2 (PTGDR2)
    Reaktivität
    • 66
    • 24
    • 13
    • 4
    • 3
    Human
    Wirt
    • 53
    • 13
    • 1
    Ratte
    Klonalität
    • 53
    • 14
    Monoklonal
    Konjugat
    • 28
    • 4
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Unkonjugiert
    Applikation
    • 28
    • 18
    • 14
    • 13
    • 13
    • 12
    • 7
    • 7
    • 4
    • 3
    • 2
    • 2
    • 1
    • 1
    Flow Cytometry (FACS)
    Marke
    BD Pharmingen™
    Produktmerkmale
    Monoclonal antibody BM16 reacts with CRTH2 (chemoattractant receptor-homologous molecule expressed on Th2 cells). CRTH2 is a member of the G protein-coupled leukocyte chemoattractant receptor family and it is expressed on Th2, but not Th1 lineage cells. It is detectable on CD4+ T cells in fresh PBMC and no significant expression on B cells and NK cells. CRTH2 is also expressed on peripheral blood basophils and eosinophils, suggesting its involvement allergic reactions. Phenotypic analysis of CD4+ T cells expressing CRTH2 demonstrated CD45RA-, CD45RO+ and CD25+. These cells produce Th2- but little or no Th1-type cytokines upon stimulation with PMA and Ionomycin. Profile of anti-CRTH2 (BM16) reactivity on HUT 78 cells analyzed by flow cytometry. Second step staining with Cat. No. 554016.

    BD Pharmingen™ Purified Rat Anti-Human CD294 - Purified - Clone BM16 - Isotype Rat IgG2a, κ - Reactivity Hu - 0.1 mg
    Aufreinigung
    The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
    Immunogen
    Transfectant cells
    Klon
    BM16
    Isotyp
    IgG2a kappa
    Top Product
    Discover our top product PTGDR2 Primärantikörper
  • Applikationshinweise
    Optimal working dilution should be determined by the investigator.
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Konzentration
    0.5 mg/mL
    Buffer
    Aqueous buffered solution containing ≤0.09 % sodium azide.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    4 °C
    Informationen zur Lagerung
    Store undiluted at 4°C.
  • Cosmi, Annunziato, Galli MIG, Maggi RME, Nagata, Romagnani: "CRTH2 is the most reliable marker for the detection of circulating human type 2 Th and type 2 T cytotoxic cells in health and disease." in: European journal of immunology, Vol. 30, Issue 10, pp. 2972-9, (2000) (PubMed).

    Nagata, Hirai, Tanaka, Ogawa, Aso, Sugamura, Nakamura, Takano: "CRTH2, an orphan receptor of T-helper-2-cells, is expressed on basophils and eosinophils and responds to mast cell-derived factor(s)." in: FEBS letters, Vol. 459, Issue 2, pp. 195-9, (1999) (PubMed).

    Nagata, Tanaka, Ogawa, Kemmotsu, Imai, Yoshie, Abe, Tada, Nakamura, Sugamura, Takano: "Selective expression of a novel surface molecule by human Th2 cells in vivo." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 162, Issue 3, pp. 1278-86, (1999) (PubMed).

  • Target
    Prostaglandin D2 Receptor 2 (PTGDR2)
    Andere Bezeichnung
    CD294 (PTGDR2 Produkte)
    Synonyme
    CD294 antikoerper, CRTH2 antikoerper, DL1R antikoerper, DP2 antikoerper, GPR44 antikoerper, Crth2 antikoerper, Grp45 antikoerper, Ptgdr2 antikoerper, Gpr44 antikoerper, prostaglandin D2 receptor 2 antikoerper, PTGDR2 antikoerper, Ptgdr2 antikoerper
    Hintergrund
    Synonyms: CRTH2
    Pathways
    Regulation of G-Protein Coupled Receptor Protein Signaling
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