ICOS Antikörper

Produktnummer ABIN2689138

Produktdetails anti-ICOS Antikörper

Target: ICOS (Inducible T-Cell Co-Stimulator (ICOS))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser ICOS Antikörper ist unkonjugiert

Applikation: Flow Cytometry (FACS)

Marke: BD Pharmingen™

Produktmerkmale: Monoclonal antibody DX29 reacts with inducible costimulatory (ICOS) molecule. ICOS is a homodimeric membrane glycoprotein, member of the CD28 family, of approximately 50 - 60 kDa, highly expressed on activated T cells. It is the receptor for B7 related protein 1 (B7RP-1) and also, like CD28, ICOS is costimulatory signal for T cell activation, proliferation and cytokine production. It is not expressed on resting or activated B cells, monocytes, NK cells, granulocytes, dendritic cells or platelets. Unlike the constitutively expressed CD28, ICOS expression is de novo. Reports describe similarities of CD28 and ICOS in T cell activation, however, it has been suggested that ICOS may play an important role in IL-10 production. In presence IL-10, purified recombinant human ICOS significantly increased in vitro B cell growth stimulated by pokeweed mitogen (PWM) and enhanced production of IgG. Profile of ICOS (DX29) reactivity on PHA-stimulated peripheral blood mononuclear cells analyzed by flow cytometry. Second step staining with Cat. No. 555988.

BD Pharmingen™ Purified Mouse Anti-Human CD278 - Purified - Clone DX29 - Isotype Mouse IgG1, κ - Reactivity Hu - 0.1 mg

Aufreinigung: The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.

Immunogen: Activated human T cells

Klon: DX29

Isotyp: IgG1 kappa

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 0.5 mg/mL

Buffer: Aqueous buffered solution containing ≤0.09 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C

Informationen zur Lagerung: Store undiluted at 4°C.

Referenzen für anti-ICOS Antikörper (ABIN2689138)

Dong, Nurieva: "Regulation of immune and autoimmune responses by ICOS." in: Journal of autoimmunity, Vol. 21, Issue 3, pp. 255-60, (2003) (PubMed).

Okamoto, Tezuka, Kato, Abe, Tsuji: "PI3-kinase and MAP-kinase signaling cascades in AILIM/ICOS- and CD28-costimulated T-cells have distinct functions between cell proliferation and IL-10 production." in: Biochemical and biophysical research communications, Vol. 310, Issue 3, pp. 691-702, (2003) (PubMed).

Sakamoto, Tezuka, Tsuji, Hori, Tamatani: "AILIM/ICOS: its expression and functional analysis with monoclonal antibodies." in: Hybridoma and hybridomics, Vol. 20, Issue 5-6, pp. 293-303, (2002) (PubMed).

Aicher, Hayden-Ledbetter, Brady, Pezzutto, Richter, Magaletti, Buckwalter, Ledbetter, Clark: "Characterization of human inducible costimulator ligand expression and function." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 164, Issue 9, pp. 4689-96, (2000) (PubMed).

Details zu ICOS

Target: ICOS (Inducible T-Cell Co-Stimulator (ICOS))

Andere Bezeichnung: CD278 (ICOS Produkte)

Synonyme: ICOS antikoerper, AILIM antikoerper, CCLP antikoerper, CRP-1 antikoerper, H4 antikoerper, Ly115 antikoerper, CD278 antikoerper, CVID1 antikoerper, Ailim antikoerper, inducible T-cell costimulator antikoerper, inducible T cell co-stimulator antikoerper, inducible T-cell co-stimulator antikoerper, ICOS antikoerper, LOC100232284 antikoerper, Icos antikoerper

Hintergrund: Synonyms: ICOS

Pathways: Cancer Immune Checkpoints