Reacts with a 302 amino acid cell surface protein termed B7-H2 (B-7 homologue 2). B7-H2 binds to a CD28-like receptor inducible costimulator (ICOS) and costimulates the proliferation and cytokine production of human T cells. It is weakly expressed on peripheral blood mononuclear cells, but it is expressed on monocyte-derived dendritic cells. This antibody could be useful in the study of dendritic cell development and/or costimulatory molecules. This antibody is routinely tested by flow cytometric analysis. Other applications were tested during antibody development only or reported in the literature. Profile of B7-H2 (2D3/B7-H2) expression on CHO-B7-H2 cells analyzed by flow cytometry. Second step staining with Cat. No. 555988.
This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Lagerung
4 °C
Informationen zur Lagerung
Store undiluted at 4°C.
Wang, Zhu, Chapoval, Dong, Tamada, Ni, Chen: "Costimulation of T cells by B7-H2, a B7-like molecule that binds ICOS." in: Blood, Vol. 96, Issue 8, pp. 2808-13, (2000) (PubMed).
Bretscher: "A two-step, two-signal model for the primary activation of precursor helper T cells." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 96, Issue 1, pp. 185-90, (1999) (PubMed).
Dong, Zhu, Tamada, Chen: "B7-H1, a third member of the B7 family, co-stimulates T-cell proliferation and interleukin-10 secretion." in: Nature medicine, Vol. 5, Issue 12, pp. 1365-9, (1999) (PubMed).