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TNFSF4 Antikörper

TNFSF4 Reaktivität: Ratte FACS Wirt: Maus Monoclonal ATM unconjugated
Produktnummer ABIN2689125
  • Target Alle TNFSF4 Antikörper anzeigen
    TNFSF4 (Tumor Necrosis Factor (Ligand) Superfamily, Member 4 (TNFSF4))
    Reaktivität
    • 55
    • 23
    • 7
    • 1
    Ratte
    Wirt
    • 46
    • 17
    • 15
    • 1
    Maus
    Klonalität
    • 45
    • 33
    Monoklonal
    Konjugat
    • 33
    • 9
    • 8
    • 8
    • 7
    • 4
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser TNFSF4 Antikörper ist unkonjugiert
    Applikation
    • 43
    • 42
    • 36
    • 6
    • 6
    • 5
    • 4
    • 3
    • 3
    • 3
    • 1
    • 1
    • 1
    Flow Cytometry (FACS)
    Marke
    BD Pharmingen™
    Produktmerkmale
    The ATM-2 antibody reacts with rat CD252 (OX-40 Ligand, OX-40L), a member of the TNF Ligand superfamily. Although there is controversy regarding mouse OX-40L expression, OX-40L has been shown to be expressed on human dendritic cells and mouse activated B lymphocytes. Rat OX-40L interacts with OX-40 Antigen (CD134) found predominantly on activated T cells. The OX-40L-OX-40 interaction is reciprocally costimulatory in that both T cells and B cells are activated in cross-linking. Rat OX-40L mRNA has been detected in various HTLV-I-transformed T-cell lines: F344-S1, WKA-S1, and ACI-S1. In addition, total rat spleen cells activated with 5 ng/mL PMA and 0.5 μg/mL ionomycin for two days showed OX-40L expression, as determined by flow cytometric analysis, with the ATM-2 mAb. As observed in the mouse and human systems, rat OX-40L also costimulates IL-2 production and proliferation of anti- D3-activated rat T cells. The ATM-2 mAb blocks the costimulatory activity of OX-40L on rat T- cell proliferation.

    BD Pharmingen™ Purified Mouse Anti-Rat CD252 - Purified - Clone ATM-2 - Isotype Mouse IgG1, κ - Reactivity Rat - 0.5 mg
    Aufreinigung
    The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
    Immunogen
    ACI-S1 rat T-cell lymphoma cell line
    Klon
    ATM
    Isotyp
    IgG1 kappa
    Top Product
    Discover our top product TNFSF4 Primärantikörper
  • Applikationshinweise
    Optimal working dilution should be determined by the investigator.
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Konzentration
    0.5 mg/mL
    Buffer
    Aqueous buffered solution containing ≤0.09 % sodium azide.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    4 °C
    Informationen zur Lagerung
    Store undiluted at 4°C.
  • Ohshima, Tanaka, Tozawa, Takahashi, Maliszewski, Delespesse: "Expression and function of OX40 ligand on human dendritic cells." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 159, Issue 8, pp. 3838-48, (1997) (PubMed).

    Calderhead, Buhlmann, van den Eertwegh, Claassen, Noelle, Fell: "Cloning of mouse Ox40: a T cell activation marker that may mediate T-B cell interactions." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 151, Issue 10, pp. 5261-71, (1993) (PubMed).

    Paterson, Jefferies, Green, Brandon, Corthesy, Puklavec, Williams: "Antigens of activated rat T lymphocytes including a molecule of 50,000 Mr detected only on CD4 positive T blasts." in: Molecular immunology, Vol. 24, Issue 12, pp. 1281-90, (1988) (PubMed).

  • Target
    TNFSF4 (Tumor Necrosis Factor (Ligand) Superfamily, Member 4 (TNFSF4))
    Andere Bezeichnung
    CD252 (TNFSF4 Produkte)
    Synonyme
    TNFSF4 antikoerper, OX40L antikoerper, TNFRSF4 antikoerper, CD134L antikoerper, CD252 antikoerper, GP34 antikoerper, OX-40L antikoerper, OX4OL antikoerper, TXGP1 antikoerper, Ath-1 antikoerper, Ath1 antikoerper, Ox40l antikoerper, Txgp1l antikoerper, gp34 antikoerper, TNF superfamily member 4 antikoerper, tumor necrosis factor (ligand) superfamily, member 4 antikoerper, TNFSF4 antikoerper, Tnfsf4 antikoerper
    Hintergrund
    Synonyms: OX-40L, OX-40 Ligand
    Pathways
    Cellular Response to Molecule of Bacterial Origin, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response, Activated T Cell Proliferation, Cancer Immune Checkpoints
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