2B4 Antikörper

Produktnummer ABIN2689111

Produktdetails anti-2B4 Antikörper

Target: 2B4 (CD244) (Natural Killer Cell Receptor 2B4 (CD244))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser 2B4 Antikörper ist unkonjugiert

Applikation: Flow Cytometry (FACS)

Marke: BD Pharmingen™

Produktmerkmale: Reacts with a 66 kDa single chain transmembrane glycoprotein. 2B4 belong to the immunoglobulin superfamily of proteins and is structurally related to CD2-like molecules. It was originally identified in the mouse as a non-MHC-restricted cytotoxicity mediator present on NK cells and CD8+ T cells. In humans, 2B4 is expressed on NK cells, CD8+ T cells, monocytes and basophils, suggesting a broader role for 2B4 in leukocyte activation and possibly a role of immunomodulation in other receptor-ligand interactions to enhance leukocyte activation. 2B4 has been clustered as CD244 in the VIIth HLDA workshop. This antibody is routinely tested by flow cytometric analysis. Other applications were tested during antibody development only or reported in the literature. Profile of CD244 (2-69) reactivity on peripheral blood lymphocytes analyzed by flow cytometry. Second step staining with Cat. No. 555988.

BD Pharmingen™ Purified Mouse Anti-Human CD244 - Purified - Clone 2-69 - Isotype Mouse IgG2a, κ - Reactivity Hu - 0.1 mg

Aufreinigung: The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.

Klon: 2

Isotyp: IgG2a kappa

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 0.5 mg/mL

Buffer: Aqueous buffered solution containing ≤0.09 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C

Informationen zur Lagerung: Store undiluted at 4°C.

Referenzen für anti-2B4 Antikörper (ABIN2689111)

Sivori, Parolini, Falco, Marcenaro, Biassoni, Bottino, Moretta, Moretta: "2B4 functions as a co-receptor in human NK cell activation." in: European journal of immunology, Vol. 30, Issue 3, pp. 787-93, (2000) (PubMed).

Nakajima, Cella, Langen, Friedlein, Colonna: "Activating interactions in human NK cell recognition: the role of 2B4-CD48." in: European journal of immunology, Vol. 29, Issue 5, pp. 1676-83, (1999) (PubMed).

Tangye, Lazetic, Woollatt, Sutherland, Lanier, Phillips: "Cutting edge: human 2B4, an activating NK cell receptor, recruits the protein tyrosine phosphatase SHP-2 and the adaptor signaling protein SAP." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 162, Issue 12, pp. 6981-5, (1999) (PubMed).

Mathew, Garni-Wagner, Land, Takashima, Stoneman, Bennett, Kumar: "Cloning and characterization of the 2B4 gene encoding a molecule associated with non-MHC-restricted killing mediated by activated natural killer cells and T cells." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 151, Issue 10, pp. 5328-37, (1993) (PubMed).

Details zu 2B4

Target: 2B4 (CD244) (Natural Killer Cell Receptor 2B4 (CD244))

Andere Bezeichnung: CD244 (CD244 Produkte)

Synonyme: CD244 antikoerper, 2B4 antikoerper, NAIL antikoerper, NKR2B4 antikoerper, Nmrk antikoerper, SLAMF4 antikoerper, C9.1 antikoerper, F730046O15Rik antikoerper, Ly90 antikoerper, CD244 molecule antikoerper, CD244 natural killer cell receptor 2B4 antikoerper, CD244 antikoerper, Cd244 antikoerper

Hintergrund: Synonyms: 2B4