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CD226 Antikörper

CD226 Reaktivität: Human FACS Wirt: Maus Monoclonal DX11 unconjugated
Produktnummer ABIN2689098
  • Target Alle CD226 Antikörper anzeigen
    CD226
    Reaktivität
    • 74
    • 20
    • 5
    • 4
    • 2
    • 1
    • 1
    Human
    Wirt
    • 54
    • 23
    • 8
    Maus
    Klonalität
    • 49
    • 35
    • 1
    Monoklonal
    Konjugat
    • 46
    • 10
    • 9
    • 6
    • 4
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser CD226 Antikörper ist unkonjugiert
    Applikation
    • 45
    • 32
    • 32
    • 16
    • 14
    • 9
    • 7
    • 4
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    Flow Cytometry (FACS)
    Marke
    BD Pharmingen™
    Produktmerkmale
    The DX11 monoclonal antibody specifically binds to CD226 which is also known as DNAX accessory molecule-1 (DNAM-1), Platelet and T cell activation antigen 1 (PTA1), or T lineage-specific activation antigen 1 antigen (TLiSA1). CD226 is a 65 kDa type 1 transmembrane glycoprotein consisting of 318 amino acid residues including two Ig-like domains. CD226 is expressed on the majority of T cells, NK cells, monocytes, platelets, and a subset of B cells, but not on granulocytes or erythrocytes. It is also present on a subset of thymocytes coexpressing high density surface CD3. CD226 is not present on normal fibroblast cell lines or tumor cell lines of epithelial or neuronal origins. CD226 is a tyrosine phosphorylated, signal-transducing molecule which participates in primary adhesion during cytotoxic T lymphocyte (CTL)- or NK cell-mediated cytotoxicity. The DX11 antibody inhibits T- and NK cell-mediated cytotoxicity against a variety of tumor cell targets, and blocks cytokine production by alloantigen-specific T cells. Profile of peripheral blood lymphocytes analyzed by flow cytometry. Second step staining with Cat. No. 555988.

    BD Pharmingen™ Purified Mouse Anti-Human CD226 - Purified - Clone DX11 - Isotype Mouse IgG1, κ - Reactivity Hu - 0.1 mg
    Aufreinigung
    The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
    Klon
    DX11
    Isotyp
    IgG1 kappa
    Top Product
    Discover our top product CD226 Primärantikörper
  • Applikationshinweise
    Optimal working dilution should be determined by the investigator.
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Konzentration
    0.5 mg/mL
    Buffer
    Aqueous buffered solution containing ≤0.09 % sodium azide.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    4 °C
    Informationen zur Lagerung
    Store undiluted at 4°C.
  • Shibuya, Campbell, Hannum, Yssel, Franz-Bacon, McClanahan, Kitamura, Nicholl, Sutherland, Lanier, Phillips: "DNAM-1, a novel adhesion molecule involved in the cytolytic function of T lymphocytes." in: Immunity, Vol. 4, Issue 6, pp. 573-81, (1996) (PubMed).

  • Target
    CD226
    Andere Bezeichnung
    CD226 (CD226 Produkte)
    Synonyme
    CD226 antikoerper, cd226 antikoerper, zgc:158817 antikoerper, BC051526 antikoerper, DNAM-1 antikoerper, DNAM1 antikoerper, Pta1 antikoerper, TLiSA1 antikoerper, PTA1 antikoerper, CD226 molecule antikoerper, CD226 antigen antikoerper, CD226 antikoerper, cd226 antikoerper, Cd226 antikoerper
    Hintergrund
    Synonyms: DNAM-1, DNAM1, PTA1, PTA-1, TLiSA1
    Pathways
    Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Cancer Immune Checkpoints
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