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IL12RB1 Antikörper (Biotin)

IL12RB1 Reaktivität: Maus FACS Wirt: Maus Monoclonal 114 Biotin
Produktnummer ABIN2689093
  • Target Alle IL12RB1 Antikörper anzeigen
    IL12RB1 (Interleukin 12 Receptor beta 1 (IL12RB1))
    Reaktivität
    • 44
    • 24
    • 24
    Maus
    Wirt
    • 57
    • 6
    • 2
    • 1
    Maus
    Klonalität
    • 60
    • 6
    Monoklonal
    Konjugat
    • 27
    • 6
    • 5
    • 4
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser IL12RB1 Antikörper ist konjugiert mit Biotin
    Applikation
    • 44
    • 13
    • 13
    • 12
    • 10
    • 8
    • 3
    • 3
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    Flow Cytometry (FACS)
    Marke
    BD Pharmingen™
    Produktmerkmale
    The 114 antibody reacts with mouse CD212 (the β1 subunit of IL-12Rβ1), originally termed IL-12Rβ, of the mouse IL-12 receptor complex. The IL-12Rβ1 subunit associates with a β2 subunit to form a heterodimeric IL-12 receptor complex. Each one of the IL-12R subunits exhibits low affinity for IL-12, but in combination, they bind IL-12 with high affinity. The IL-12Rβ1 subunit interacts primarily with IL-12 p40 whereas the IL-12Rβ2 binds both to IL-12 p40 and IL-12 p35. IL-12Rβ1 is required for high affinity binding of IL-12 but IL-12Rβ2 is required for signaling. IL-12Rβ1 has more recently been described to bind IL-23, a heterodimer formed of the p40 subunit from IL-12, and p19. The cytoplasmic regions of the β1 and β2 subunits contain the box1 and box2 motifs found in other cytokine receptors such as gp130, LIFR and G-CSFR. IL-12Rβ1 are primarily expressed by activated T cells and NK cells. Experiments with IL-12Rβ1 deficient mice have shown that IL-12Rβ1 is necessary for mouse T and NK cell responsiveness to IL-12 p75. The 114 antibody was generated by immunizing IL-12Rβ1 deficient mice of (129 x BALB/c)F1 background with mouse Ba/F3 cells that were stably transfected with IL-12Rβ1.

    BD Pharmingen™ Biotin Mouse Anti-Mouse CD212 - Biotin - Clone 114 - Isotype Mouse IgG2a, κ - Reactivity Ms - 0.1 mg
    Aufreinigung
    The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
    Immunogen
    IL-12Rbeta1 Transfected Cell Line
    Klon
    114
    Isotyp
    IgG2a kappa
    Top Product
    Discover our top product IL12RB1 Primärantikörper
  • Applikationshinweise
    Optimal working dilution should be determined by the investigator.
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Konzentration
    0.5 mg/mL
    Buffer
    Aqueous buffered solution containing ≤0.09 % sodium azide.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handhabung
    The antibody was conjugated with biotin under optimum conditions, and unreacted biotin was removed.
    Lagerung
    4 °C
    Informationen zur Lagerung
    Store undiluted at 4°C.
  • Wu, Wang, Gadina, OShea, Presky, Magram: "IL-12 receptor beta 2 (IL-12R beta 2)-deficient mice are defective in IL-12-mediated signaling despite the presence of high affinity IL-12 binding sites." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 165, Issue 11, pp. 6221-8, (2000) (PubMed).

    Wang, Wilkinson, Podlaski, Wu, Stern, Presky, Magram: "Characterization of mouse interleukin-12 p40 homodimer binding to the interleukin-12 receptor subunits." in: European journal of immunology, Vol. 29, Issue 6, pp. 2007-13, (1999) (PubMed).

    Gately, Renzetti, Magram, Stern, Adorini, Gubler, Presky: "The interleukin-12/interleukin-12-receptor system: role in normal and pathologic immune responses." in: Annual review of immunology, Vol. 16, pp. 495-521, (1998) (PubMed).

    Presky, Minetti, Gillessen, Wilkinson, Wu, Gubler, Chizzonite, Gately: "Analysis of the multiple interactions between IL-12 and the high affinity IL-12 receptor complex." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 160, Issue 5, pp. 2174-9, (1998) (PubMed).

    Wu, Ferrante, Gately, Magram: "Characterization of IL-12 receptor beta1 chain (IL-12Rbeta1)-deficient mice: IL-12Rbeta1 is an essential component of the functional mouse IL-12 receptor." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 159, Issue 4, pp. 1658-65, (1997) (PubMed).

    Presky, Yang, Minetti, Chua, Nabavi, Wu, Gately, Gubler: "A functional interleukin 12 receptor complex is composed of two beta-type cytokine receptor subunits." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 93, Issue 24, pp. 14002-7, (1997) (PubMed).

    Chua, Wilkinson, Presky, Gubler: "Cloning and characterization of a mouse IL-12 receptor-beta component." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 155, Issue 9, pp. 4286-94, (1995) (PubMed).

    Stahl, Yancopoulos: "The alphas, betas, and kinases of cytokine receptor complexes." in: Cell, Vol. 74, Issue 4, pp. 587-90, (1993) (PubMed).

  • Target
    IL12RB1 (Interleukin 12 Receptor beta 1 (IL12RB1))
    Andere Bezeichnung
    CD212 (IL12RB1 Produkte)
    Synonyme
    Il12rb antikoerper, IL12RB1 antikoerper, IL-12R antikoerper, CD212 antikoerper, IL-12R-BETA1 antikoerper, IL12RB antikoerper, IL-12R[b] antikoerper, interleukin 12 receptor subunit beta 1 antikoerper, interleukin 12 receptor, beta 1 antikoerper, Il12rb1 antikoerper, IL12RB1 antikoerper
    Hintergrund
    Synonyms: IL-12 Receptor β1 chain
    Pathways
    JAK-STAT Signalweg, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Activated T Cell Proliferation
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