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CD1d Antikörper (Biotin)

CD1D Reaktivität: Maus FACS, IF, IHC (fro) Wirt: Ratte Monoclonal 1B1 Biotin
Produktnummer ABIN2689069
  • Target Alle CD1d (CD1D) Antikörper anzeigen
    CD1d (CD1D) (CD1d Molecule (CD1D))
    Reaktivität
    • 63
    • 42
    • 17
    • 4
    Maus
    Wirt
    • 59
    • 21
    • 20
    Ratte
    Klonalität
    • 61
    • 39
    Monoklonal
    Konjugat
    • 44
    • 10
    • 8
    • 7
    • 6
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    Dieser CD1d Antikörper ist konjugiert mit Biotin
    Applikation
    • 46
    • 41
    • 21
    • 12
    • 10
    • 7
    • 6
    • 4
    • 4
    • 4
    • 3
    • 3
    • 1
    • 1
    • 1
    • 1
    Flow Cytometry (FACS), Immunofluorescence (IF), Immunohistochemistry (Frozen Sections) (IHC (fro))
    Marke
    BD Pharmingen™
    Produktmerkmale
    The 1B1 antibody reacts with CD1d, a 48- kDa glycoprotein with structural homology to the major histocompatibility complex (MHC) class I molecules. The structure, expression, and functions of CD1 antigens are complex and have been reviewed. mAb 1B1 detects CD1d at varying levels on most types of bone marrow and peripheral leukocytes and on epithelial, dendritic, and lymphoid cells in the thymus. It appears to recognize CD1d only in association with β2m. CD1d has been reported to be expressed by gastrointestinal tract epithelium and in the cytoplasm of hepatocytes as detected viaimmunohistochemical staining of frozen sections with mAb 3C11 (Cat. No. 559871, for the purified antibody), suggesting a possible role for CD1d in mucosal immunity. However, CD1d expression was not detectable, via flow cytometry, on intestinal epithelial cells in studies using the anti-CD1d mAbs 3C11, 1B1, and 9C7. The 1B1 antibody competes with mAb 3C11 in binding to mouse splenocytes. This antibody is routinely tested by flow cytometric analysis. Other applications were tested during antibody development only or reported in the literature.

    BD Pharmingen™ Biotin Rat Anti-Mouse CD1d - Biotin - Clone 1B1 - Isotype Rat IgG2b, κ - Reactivity Ms - 0.5 mg
    Aufreinigung
    The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
    Immunogen
    Mouse Cd1.1 cDNA-transfected RMA-S mouse T lymphoma and mouse L929 cells
    Klon
    1B1
    Isotyp
    IgG2b kappa
    Top Product
    Discover our top product CD1D Primärantikörper
  • Applikationshinweise
    Optimal working dilution should be determined by the investigator.
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Konzentration
    0.5 mg/mL
    Buffer
    Aqueous buffered solution containing ≤0.09 % sodium azide.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handhabung
    The antibody was conjugated with biotin under optimum conditions, and unreacted biotin was removed.
    Lagerung
    4 °C
    Informationen zur Lagerung
    Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
  • Prigozy, Naidenko, Qasba, Elewaut, Brossay, Khurana, Natori, Koezuka, Kulkarni, Kronenberg: "Glycolipid antigen processing for presentation by CD1d molecules." in: Science (New York, N.Y.), Vol. 291, Issue 5504, pp. 664-7, (2001) (PubMed).

    Porcelli, Modlin: "The CD1 system: antigen-presenting molecules for T cell recognition of lipids and glycolipids." in: Annual review of immunology, Vol. 17, pp. 297-329, (1999) (PubMed).

    Szalay, Ladel, Blum, Brossay, Kronenberg, Kaufmann: "Cutting edge: anti-CD1 monoclonal antibody treatment reverses the production patterns of TGF-beta 2 and Th1 cytokines and ameliorates listeriosis in mice." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 162, Issue 12, pp. 6955-8, (1999) (PubMed).

    Brossay, Tangri, Bix, Cardell, Locksley, Kronenberg: "Mouse CD1-autoreactive T cells have diverse patterns of reactivity to CD1+ targets." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 160, Issue 8, pp. 3681-8, (1998) (PubMed).

    Amano, Baumgarth, Dick, Brossay, Kronenberg, Herzenberg, Strober: "CD1 expression defines subsets of follicular and marginal zone B cells in the spleen: beta 2-microglobulin-dependent and independent forms." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 161, Issue 4, pp. 1710-7, (1998) (PubMed).

    Roark, Park, Jayawardena, Kavita, Shannon, Bendelac: "CD1.1 expression by mouse antigen-presenting cells and marginal zone B cells." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 160, Issue 7, pp. 3121-7, (1998) (PubMed).

    Brossay, Jullien, Cardell, Sydora, Burdin, Modlin, Kronenberg: "Mouse CD1 is mainly expressed on hemopoietic-derived cells." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 159, Issue 3, pp. 1216-24, (1997) (PubMed).

    Sydora, Brossay, Hagenbaugh, Kronenberg, Cheroutre: "TAP-independent selection of CD8+ intestinal intraepithelial lymphocytes." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 156, Issue 11, pp. 4209-16, (1996) (PubMed).

    Bleicher, Balk, Hagen, Blumberg, Flotte, Terhorst: "Expression of murine CD1 on gastrointestinal epithelium." in: Science (New York, N.Y.), Vol. 250, Issue 4981, pp. 679-82, (1990) (PubMed).

  • Target
    CD1d (CD1D) (CD1d Molecule (CD1D))
    Andere Bezeichnung
    CD1d (CD1D Produkte)
    Synonyme
    CD1A antikoerper, R3 antikoerper, CD1D antikoerper, CD1D1 antikoerper, CD1d molecule antikoerper, CD1D antigen, d polypeptide antikoerper, CD1D antikoerper
    Hintergrund
    Synonyms: CD1.1, Ly-38
    Pathways
    Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process
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