CCR4 Antikörper (Biotin)

Produktnummer ABIN2689051

Produktdetails anti-CCR4 Antikörper (Biotin)

Target: CCR4 (Chemokine (C-C Motif) Receptor 4 (CCR4))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser CCR4 Antikörper ist konjugiert mit Biotin

Applikation: Flow Cytometry (FACS)

Marke: BD Pharmingen™

Produktmerkmale: The monoclonal antibody 1G1 reacts with CD194, also known as the human CC Chemokine Receptor type 4 (CCR4). CCR4 is expressed on activated Th2 cells, regulatory T cells, activated NK cells, basophils, monocytes and platelets. CCR4 is a seven-transmembrane, G-protein-coupled receptor, and is the specific receptor for CC chemokines, CCL22/MDC/Macrophage-Derived Chemokine and CCL17/TARC/Thymus and Activation-Regulated Chemokine. It has been reported that CCR4 mRNA is expressed mainly in the thymus and spleen. The human CCR4 gene has been mapped to chromosome 3p24. The purified form of this antibody has been reported not to be a neutralizing antibody. The immunogen used to generate the 1G1 hybridoma has been reported to be human CCR4 transfected L1.2 mouse lymphoma cells.

BD Pharmingen™ Biotin Mouse Anti-Human CD194 - Biotin - Clone 1G1 - Isotype Mouse IgG1, κ - Reactivity Hu - 0.5 mg

Aufreinigung: The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.

Immunogen: Human CCR4 Transfected Cell Line

Klon: 1G1

Isotyp: IgG1 kappa

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 0.5 mg/mL

Buffer: Aqueous buffered solution containing ≤0.09 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: The antibody was conjugated with biotin under optimum conditions, and unreacted biotin was removed.

Lagerung: 4 °C

Informationen zur Lagerung: Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.

Referenzen für anti-CCR4 Antikörper (Biotin) (ABIN2689051)

Andrew, Ruffing, Kim, Miao, Heath, Li, Murphy, Campbell, Butcher, Wu: "C-C chemokine receptor 4 expression defines a major subset of circulating nonintestinal memory T cells of both Th1 and Th2 potential." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 166, Issue 1, pp. 103-11, (2001) (PubMed).

Campbell, Haraldsen, Pan, Rottman, Qin, Ponath, Andrew, Warnke, Ruffing, Kassam, Wu, Butcher: "The chemokine receptor CCR4 in vascular recognition by cutaneous but not intestinal memory T cells." in: Nature, Vol. 400, Issue 6746, pp. 776-80, (1999) (PubMed).

Bonecchi, Bianchi, Bordignon, DAmbrosio, Lang, Borsatti, Sozzani, Allavena, Gray, Mantovani, Sinigaglia: "Differential expression of chemokine receptors and chemotactic responsiveness of type 1 T helper cells (Th1s) and Th2s." in: The Journal of experimental medicine, Vol. 187, Issue 1, pp. 129-34, (1998) (PubMed).

DAmbrosio, Iellem, Bonecchi, Mazzeo, Sozzani, Mantovani, Sinigaglia: "Selective up-regulation of chemokine receptors CCR4 and CCR8 upon activation of polarized human type 2 Th cells." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 161, Issue 10, pp. 5111-5, (1998) (PubMed).

Imai, Chantry, Raport, Wood, Nishimura, Godiska, Yoshie, Gray: "Macrophage-derived chemokine is a functional ligand for the CC chemokine receptor 4." in: The Journal of biological chemistry, Vol. 273, Issue 3, pp. 1764-8, (1998) (PubMed).

Sallusto, Lenig, Mackay, Lanzavecchia: "Flexible programs of chemokine receptor expression on human polarized T helper 1 and 2 lymphocytes." in: The Journal of experimental medicine, Vol. 187, Issue 6, pp. 875-83, (1998) (PubMed).

Imai, Baba, Nishimura, Kakizaki, Takagi, Yoshie: "The T cell-directed CC chemokine TARC is a highly specific biological ligand for CC chemokine receptor 4." in: The Journal of biological chemistry, Vol. 272, Issue 23, pp. 15036-42, (1997) (PubMed).

Samson, Soularue, Vassart, Parmentier: "The genes encoding the human CC-chemokine receptors CC-CKR1 to CC-CKR5 (CMKBR1-CMKBR5) are clustered in the p21.3-p24 region of chromosome 3." in: Genomics, Vol. 36, Issue 3, pp. 522-6, (1997) (PubMed).

Power, Meyer, Nemeth, Bacon, Hoogewerf, Proudfoot, Wells: "Molecular cloning and functional expression of a novel CC chemokine receptor cDNA from a human basophilic cell line." in: The Journal of biological chemistry, Vol. 270, Issue 33, pp. 19495-500, (1995) (PubMed).

Details zu CCR4

Target: CCR4 (Chemokine (C-C Motif) Receptor 4 (CCR4))

Andere Bezeichnung: CD194 (CCR4 Produkte)

Synonyme: CC-CKR-4 antikoerper, CD194 antikoerper, CKR4 antikoerper, CMKBR4 antikoerper, ChemR13 antikoerper, HGCN:14099 antikoerper, K5-5 antikoerper, Ccr4 antikoerper, C-C CKR-4 antikoerper, CHEMR1 antikoerper, Cmkbr4 antikoerper, LESTR antikoerper, Sdf1r antikoerper, C-C motif chemokine receptor 4 antikoerper, chemokine (C-C motif) receptor 4 antikoerper, CCR4 antikoerper, Ccr4 antikoerper

Hintergrund: Synonyms: CCR4, C-C chemokine receptor type 4, CMKBR4, K5-5