CD180 Antikörper

Produktnummer ABIN2689036

Produktdetails anti-CD180 Antikörper

Target: CD180 (CD180 Molecule (CD180))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser CD180 Antikörper ist unkonjugiert

Applikation: Flow Cytometry (FACS)

Marke: BD Pharmingen™

Produktmerkmale: Reacts with RP105/Bgp95, a 95-105 kDa type I membrane protein consisting of extracellular leucine-rich repeats and a short cytoplasmic domain. It is expressed on mantle zone B cells, but weakly on germinal center B cells. RP105/Bgp95 is also expressed on peripheral blood monocytes, dendritic cells, and a subset of peripheral blood lymphocytes. The extracellular domain associates with a molecule called MD-1 to form a cell surface receptor complex RP105/Bgp95/MD- 1. This receptor belongs to the family of toll-like receptors (TLR). Studies show that RP105/Bgp95/MD-1, working in concert with TLR4, controls B cell recognition and signaling of lipopolysaccharide (LPS). Reports on functional studies show that G28-8 monoclonal antibody can induce a G0 to G1 cell cycle transition and was synergistic with PMA, anti-μ, or anti-CD40 in inducing proliferation of resting B cells. Profile of peripheral blood lymphocytes analyzed by flow cytometry. Second step staining with Cat. No. 555988.

BD Pharmingen™ Purified Mouse Anti-Human CD180 - Purified - Clone G28-8 - Isotype Mouse IgG1, κ - Reactivity Hu - 0.1 mg

Aufreinigung: The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.

Klon: G28

Isotyp: IgG1 kappa

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 0.5 mg/mL

Buffer: Aqueous buffered solution containing ≤0.09 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C

Informationen zur Lagerung: Store undiluted at 4°C.

Referenzen für anti-CD180 Antikörper (ABIN2689036)

Ogata, Su, Miyake, Nagai, Akashi, Mecklenbräuker, Rajewsky, Kimoto, Tarakhovsky: "The toll-like receptor protein RP105 regulates lipopolysaccharide signaling in B cells." in: The Journal of experimental medicine, Vol. 192, Issue 1, pp. 23-9, (2000) (PubMed).

Roshak, Anderson, Holmes, Jonak, Bolognese, Terrett, Marshall: "Anti-human RP105 sera induces lymphocyte proliferation." in: Journal of leukocyte biology, Vol. 65, Issue 1, pp. 43-9, (1999) (PubMed).

Fugier-Vivier, de Bouteiller, Guret, Fossiez, Banchereau, Mattei, Aït-Yahia, Garcia, Lebecque, Liu: "Molecular cloning of human RP105." in: European journal of immunology, Vol. 27, Issue 7, pp. 1824-7, (1997) (PubMed).

Valentine, Clark, Shu, Norris, Ledbetter: "Antibody to a novel 95-kDa surface glycoprotein on human B cells induces calcium mobilization and B cell activation." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 140, Issue 12, pp. 4071-8, (1988) (PubMed).

Details zu CD180

Target: CD180 (CD180 Molecule (CD180))

Andere Bezeichnung: CD180 (CD180 Produkte)

Synonyme: Ly78 antikoerper, CD180 antikoerper, LY64 antikoerper, RP105 antikoerper, F630107B15 antikoerper, CD180 molecule antikoerper, CD180 antigen antikoerper, Cd180 antikoerper, CD180 antikoerper

Hintergrund: Synonyms: RP105

Pathways: Cellular Response to Molecule of Bacterial Origin, Toll-Like Receptors Cascades