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SIRPA Antikörper

SIRPA Reaktivität: Maus WB, FACS, IP, IF, BR Wirt: Ratte Monoclonal P84 unconjugated
Produktnummer ABIN2689017
  • Target Alle SIRPA Antikörper anzeigen
    SIRPA (Signal-Regulatory Protein alpha (SIRPA))
    Reaktivität
    • 72
    • 45
    • 35
    • 10
    • 8
    • 4
    • 3
    • 3
    Maus
    Wirt
    • 59
    • 34
    • 6
    • 1
    Ratte
    Klonalität
    • 56
    • 44
    Monoklonal
    Konjugat
    • 47
    • 12
    • 6
    • 5
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser SIRPA Antikörper ist unkonjugiert
    Applikation
    • 58
    • 53
    • 21
    • 20
    • 15
    • 14
    • 11
    • 10
    • 9
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB), Flow Cytometry (FACS), Immunoprecipitation (IP), Immunofluorescence (IF), Blocking Reagent (BR)
    Marke
    BD Pharmingen™
    Produktmerkmale
    The P84 antibody reacts with CD172a, also known as SIgnal-Regulatory Protein α (SIRPα), Src Homology 2 domain-containing protein tyrosine Phosphatase (SHP) Substrate 1 (SHPS-1), or Brain Immunoglobulin-like molecule with Tyrosine-based activation motifs (BIT). CD172a is an adhesion molecule of the Ig superfamily which is expressed on neurons in the central nervous system and the retina, on macrophages, and on bone-marrow myeloid cells. Its ligand, CD47, or Integrin-Associated Protein (IAP), is expressed by a wide variety of cells. CD172a and CD47 are proposed to mediate bi-directional signaling to modify neural synaptic activity and regulate the phagocytic activities of macrophages. Two-color analysis of CD172a expression on bone-marrow myeloid cells. BALB/c bone-marrow leukocytes were stained with either purified rat IgG1 isotype control mAb (left panel) or purified mAb P84 (right panel), followed by FITC-conjugated anti-rat IgG1 mAb RG11/39.4 (Cat. No. 553892, both panels), then PE-conjugated anti-mouse CD11b (Mac-1) mAb M1/70 (Cat. No. 557397/553311). Total viable leukocytes were selected by exclusion of propidium iodide. Flow cytometry was performed on a FACSCalibura .

    BD Pharmingen™ Purified Rat Anti-Mouse CD172a - Purified - Clone P84 - Isotype Rat IgG1, κ - Reactivity Ms - 0.1 mg
    Aufreinigung
    The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
    Immunogen
    Membrane fractions from mouse brain
    Klon
    P84
    Isotyp
    IgG1 kappa
    Top Product
    Discover our top product SIRPA Primärantikörper
  • Applikationshinweise
    Optimal working dilution should be determined by the investigator.
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Konzentration
    0.5 mg/mL
    Buffer
    Aqueous buffered solution containing ≤0.09 % sodium azide.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    4 °C
    Informationen zur Lagerung
    Store undiluted at 4°C.
  • Mi, Jiang, Weng, Lindberg, Narayanan, Lagenaur: "Expression of a synapse-associated membrane protein, P84/SHPS-1, and its ligand, IAP/CD47, in mouse retina." in: The Journal of comparative neurology, Vol. 416, Issue 3, pp. 335-44, (2000) (PubMed).

    Gresham, Dale, Potter, Chang, Vines, Lowell, Lagenaur, Willman: "Negative regulation of phagocytosis in murine macrophages by the Src kinase family member, Fgr." in: The Journal of experimental medicine, Vol. 191, Issue 3, pp. 515-28, (2000) (PubMed).

    Oldenborg, Zheleznyak, Fang, Lagenaur, Gresham, Lindberg: "Role of CD47 as a marker of self on red blood cells." in: Science (New York, N.Y.), Vol. 288, Issue 5473, pp. 2051-4, (2000) (PubMed).

    Jiang, Lagenaur, Narayanan: "Integrin-associated protein is a ligand for the P84 neural adhesion molecule." in: The Journal of biological chemistry, Vol. 274, Issue 2, pp. 559-62, (1999) (PubMed).

    Veillette, Thibaudeau, Latour: "High expression of inhibitory receptor SHPS-1 and its association with protein-tyrosine phosphatase SHP-1 in macrophages." in: The Journal of biological chemistry, Vol. 273, Issue 35, pp. 22719-28, (1998) (PubMed).

    Comu, Weng, Olinsky, Ishwad, Mi, Hempel, Watkins, Lagenaur, Narayanan: "The murine P84 neural adhesion molecule is SHPS-1, a member of the phosphatase-binding protein family." in: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 17, Issue 22, pp. 8702-10, (1997) (PubMed).

    Chuang, Lagenaur: "Central nervous system antigen P84 can serve as a substrate for neurite outgrowth." in: Developmental biology, Vol. 137, Issue 2, pp. 219-32, (1990) (PubMed).

  • Target
    SIRPA (Signal-Regulatory Protein alpha (SIRPA))
    Andere Bezeichnung
    CD172a (SIRPA Produkte)
    Synonyme
    BIT antikoerper, CD172A antikoerper, MFR antikoerper, MYD-1 antikoerper, P84 antikoerper, PTPNS1 antikoerper, SHPS1 antikoerper, SIRP antikoerper, SIRPA antikoerper, SIRP-A1 antikoerper, SIRP-B1 antikoerper, AI835480 antikoerper, Bit antikoerper, CD172a antikoerper, Ptpns1 antikoerper, SHP-1 antikoerper, SHPS-1 antikoerper, swc3 antikoerper, signal regulatory protein alpha antikoerper, myeloperoxidase antikoerper, signal-regulatory protein alpha antikoerper, tyrosine-protein phosphatase non-receptor type substrate 1 antikoerper, SIRPA antikoerper, MPO antikoerper, LOC458039 antikoerper, LOC100400378 antikoerper, LOC100590224 antikoerper, Sirpa antikoerper
    Hintergrund
    Synonyms: SIRPα, SHPS-1, BIT
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