Reacts with an 80 kD disulfide-linked homodimer, type II membrane glycoprotein, also referred to as NKR-P1A. CD161 is expressed on most NK cells and on subsets of CD4+ and CD8+ T cells. Reports indicate that CD161 is expressed preferentially on CD45RO+ T cells, however, it can be found on a subset of thymocytes and fetal liver T cells. Its function has not been fully elucidated, but reports indicate that NKR-P1A may serve as a specific receptor for some NK cell targets. This antibody is routinely tested by flow cytometric analysis. Other applications were tested during antibody development only or reported in the literature. Profile of peripheral blood lymphocytes analyzed on a FACScan
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