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Angiotensin I Converting Enzyme 1 Antikörper

ACE Reaktivität: Human FACS Wirt: Maus Monoclonal BB9 unconjugated
Produktnummer ABIN2688976
  • Target Alle Angiotensin I Converting Enzyme 1 (ACE) Antikörper anzeigen
    Angiotensin I Converting Enzyme 1 (ACE) (Angiotensin I Converting Enzyme (Peptidyl-Dipeptidase A) 1 (ACE))
    Reaktivität
    • 103
    • 54
    • 51
    • 22
    • 12
    • 8
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    Human
    Wirt
    • 90
    • 30
    • 3
    • 1
    • 1
    Maus
    Klonalität
    • 83
    • 42
    Monoklonal
    Konjugat
    • 61
    • 16
    • 7
    • 4
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    Dieser Angiotensin I Converting Enzyme 1 Antikörper ist unkonjugiert
    Applikation
    • 97
    • 45
    • 44
    • 31
    • 26
    • 26
    • 15
    • 10
    • 10
    • 6
    • 6
    • 5
    • 3
    • 3
    • 3
    • 1
    • 1
    • 1
    Flow Cytometry (FACS)
    Marke
    BD Pharmingen™
    Produktmerkmale
    The BB9 Monoclonal antibody specifically binds Angiotensin-converting enzyme (ACE) which is also known as Dipeptidyl carboxypeptidase 1 (DCP1) or CD143. CD143 is a type I transmembrane glycoprotein that functions as a zinc metallopeptidase involved with the metabolism of angiotensin, bradykinin, and other oligopeptides. It is expressed on primitive hematopoietic progenitor cells (HPC). BB9 reacts with stromal cells, a minor subset of human bone marrow cells, it does not react with peripheral blood leucocytes. BB9 recognizes a subset of CD34+CD90+ cells that demonstrate low or absent expression of CD38, low retention of Rhodamine 123 and are Ki-67-negative. CD34+BB9+ cells are able to sustain hematopoiesis in pre-CFU culture stimulated with IL-3, IL-6, G-CSF, and SCF. BB9 also reacts with a subset of CD34+ cells from mobilized peripheral blood. This antibody was generated using human bone marrow-derived stromal cells as immunogen. Flow cytometric analysis of CD143 expression on human bone marrow cells. Human bone marrow cells were stained with APC Anti-Human CD34 (hematopoietic progenitor cell marker) and Purified Mouse Anti-Human Angiotensin Converting Enzyme (CD143) followed by FITC Goat Anti-Mouse IgG/IgM (Cat. No. 555988). The fluorescence histograms were derived from gated events with the forward and side light-scatter characteristics of viable cells. Flow cytometric analysis of CD143 expression on human bone marrow cell line. HEL 92.1.7 (Human bone marrow erythroblast, ATCC TIB-180) cells were stained with either Purified Mouse IgG1, κ Isotype Control (Cat. No. 555746, Dashed line histogram) or Purified Mouse Anti-Human Angiotensin Converting Enzyme (CD143) (Solid line historgram), followed by FITC Goat Anti-Mouse IgG/IgM (Cat. No. 555988). The fluorescence histograms were derived from gated events with the forward and side light-scatter characteristics of viable cells.

    BD Pharmingen™ Purified Mouse Anti-Human Angiotensin Converting Enzyme (CD143) - Purified - Clone BB9 - Isotype Mouse IgG1, κ - Reactivity Hu - 0.1 mg
    Aufreinigung
    The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
    Immunogen
    Human bone marrow-derived stromal cells
    Klon
    BB9
    Isotyp
    IgG1 kappa
    Top Product
    Discover our top product ACE Primärantikörper
  • Applikationshinweise
    Optimal working dilution should be determined by the investigator.
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Konzentration
    0.5 mg/mL
    Buffer
    Aqueous buffered solution containing ≤0.09 % sodium azide.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    4 °C
    Informationen zur Lagerung
    Store undiluted at 4°C.
  • Sinka, Biasch, Khazaal, Péault, Tavian: "Angiotensin-converting enzyme (CD143) specifies emerging lympho-hematopoietic progenitors in the human embryo." in: Blood, Vol. 119, Issue 16, pp. 3712-23, (2012) (PubMed).

    Zambidis, Park, Yu, Tam, Levine, Yuan, Pryzhkova, Péault: "Expression of angiotensin-converting enzyme (CD143) identifies and regulates primitive hemangioblasts derived from human pluripotent stem cells." in: Blood, Vol. 112, Issue 9, pp. 3601-14, (2008) (PubMed).

    Jokubaitis, Sinka, Driessen, Whitty, Haylock, Bertoncello, Smith, Péault, Tavian, Simmons: "Angiotensin-converting enzyme (CD143) marks hematopoietic stem cells in human embryonic, fetal, and adult hematopoietic tissues." in: Blood, Vol. 111, Issue 8, pp. 4055-63, (2008) (PubMed).

  • Target
    Angiotensin I Converting Enzyme 1 (ACE) (Angiotensin I Converting Enzyme (Peptidyl-Dipeptidase A) 1 (ACE))
    Andere Bezeichnung
    CD143 (ACE Produkte)
    Synonyme
    ACE1 antikoerper, CD143 antikoerper, DCP antikoerper, DCP1 antikoerper, ICH antikoerper, MVCD3 antikoerper, AW208573 antikoerper, Dcp1 antikoerper, StsRR92 antikoerper, dcp antikoerper, ace1 antikoerper, dcp1 antikoerper, xace antikoerper, cd143 antikoerper, ACE antikoerper, angiotensin I converting enzyme antikoerper, angiotensin I converting enzyme (peptidyl-dipeptidase A) 1 antikoerper, angiotensin-converting enzyme antikoerper, angiotensin I converting enzyme (peptidyl-dipeptidase A) 3 antikoerper, angiotensin-converting enzyme-like antikoerper, ACE antikoerper, Ace antikoerper, ace antikoerper, CpipJ_CPIJ009106 antikoerper, ACE3 antikoerper, LOC101824864 antikoerper
    Hintergrund
    Synonyms: ACE1, DCP1, Kininase II
    Pathways
    ACE Inhibitor Pathway, Peptide Hormone Metabolism, Regulation of Systemic Arterial Blood Pressure by Hormones, Feeding Behaviour, Smooth Muscle Cell Migration
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