Reacts with a 45-47 kDa, single chain, type I transmembrane protein also known as Tissue Factor (TF). CD142 has been referred in the literature as coagulation Factor III or thromboplastin and it is expressed on activated endothelial cells and lipopolysaccharide (LPS)-stimulated monocytes/macrophages. TF associates with factor VIIa to form a complex and acts as an enzyme that initiates the blood coagulation cascade. It is known as the major initiator of clotting in normal hemostasis. CD142 can be induced by various inflammatory mediators in monocytes and vascular endothelial cells. This antibody is useful in inflammation, thrombosis and hemostasis research. Profile of LPS-stimulated peripheral blood monocytes analyzed by flow cytometry
This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Lagerung
4 °C
Informationen zur Lagerung
Store undiluted at 4°C.
Carson, Perry, Pirruccello: "Fibroblast tissue factor: calcium and ionophore induce shape changes, release of membrane vesicles, and redistribution of tissue factor antigen in addition to increased procoagulant activity." in: Blood, Vol. 84, Issue 2, pp. 526-34, (1994) (PubMed).
McComb, Miller, Carson: "Tissue factor antigen in senile plaques of Alzheimer's disease." in: The American journal of pathology, Vol. 139, Issue 3, pp. 491-4, (1991) (PubMed).
Target
Tissue factor (F3)
(Coagulation Factor III (thromboplastin, Tissue Factor) (F3))