CD137 Antikörper

Produktnummer ABIN2688962

Produktdetails anti-CD137 Antikörper

Target: CD137 (TNFRSF9) (Tumor Necrosis Factor Receptor Superfamily, Member 9 (TNFRSF9))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser CD137 Antikörper ist unkonjugiert

Applikation: Flow Cytometry (FACS)

Marke: BD Pharmingen™

Produktmerkmale: Reacts with 4-1BB, a 30 kDa glycoprotein expressed on activated T cells. 4-1BB can be detected on Con A or PHA-stimulated peripheral blood T cells (CD4+ and CD8+) and on CEM cells (human T-cell leukemia) following 2 day PMA and ionomycin stimulation, but not on resting T cells. 4-1BB is reported to be a participant in T-cell activation, being responsible for rescuing T cells from activation-induced apoptosis, upregulation of Th1-type, T-helper cells, downregulation of Th2-type cytokine production, and induction of cell adhesion to fibronectin. This antibody is routinely tested by flow cytometric analysis. Other applications were tested during antibody development only or reported in the literature. Profile of Con A-stimulated peripheral blood mononuclear cells (PBMC) analyzed by flow cytometry. Second step staining with Cat. No. 555988.

BD Pharmingen™ Purified Mouse Anti-Human CD137 - Purified - Clone 4B4-1 - Isotype Mouse IgG1, κ - Reactivity Hu - 0.1 mg

Aufreinigung: The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.

Klon: 4B4

Isotyp: IgG1 kappa

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 0.5 mg/mL

Buffer: Aqueous buffered solution containing ≤0.09 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C

Informationen zur Lagerung: Store undiluted at 4°C.

Referenzen für anti-CD137 Antikörper (ABIN2688962)

Garni-Wagner, Lee, Kim, Wilde, Kang, Kwon: "4-1BB is expressed on CD45RAhiROhi transitional T cell in humans." in: Cellular immunology, Vol. 169, Issue 1, pp. 91-8, (1996) (PubMed).

Zhou, Kim, Hurtado, Lee, Kim, Pollok, Kwon: "Characterization of human homologue of 4-1BB and its ligand." in: Immunology letters, Vol. 45, Issue 1-2, pp. 67-73, (1995) (PubMed).

Hurtado, Kim, Pollok, Lee, Kwon: "Potential role of 4-1BB in T cell activation. Comparison with the costimulatory molecule CD28." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 155, Issue 7, pp. 3360-7, (1995) (PubMed).

Details zu CD137

Target: CD137 (TNFRSF9) (Tumor Necrosis Factor Receptor Superfamily, Member 9 (TNFRSF9))

Andere Bezeichnung: CD137 (TNFRSF9 Produkte)

Synonyme: TNFRSF9 antikoerper, zgc:136557 antikoerper, 4-1BB antikoerper, CD137 antikoerper, CDw137 antikoerper, ILA antikoerper, A930040I11Rik antikoerper, AA408498 antikoerper, AI325004 antikoerper, Cd137 antikoerper, Ly63 antikoerper, tumor necrosis factor receptor superfamily member 9 antikoerper, TNF receptor superfamily member 9 antikoerper, tumor necrosis factor receptor superfamily, member 9a antikoerper, tumor necrosis factor receptor superfamily, member 9 antikoerper, TNFRSF9 antikoerper, tnfrsf9a antikoerper, Tnfrsf9 antikoerper

Hintergrund: Synonyms: 4-1BB

Pathways: Cancer Immune Checkpoints