TNFRSF1A Antikörper

Produktnummer ABIN2688922

Produktdetails anti-TNFRSF1A Antikörper

Target: TNFRSF1A (Tumor Necrosis Factor Receptor Superfamily, Member 1A (TNFRSF1A))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser TNFRSF1A Antikörper ist unkonjugiert

Applikation: ELISA

Marke: BD Pharmingen™

Produktmerkmale: The MABTNFR1-A1 antibody reacts with the extracellular domain of the 55 kDa receptor for the human cytokines: TNF (aka tumor necrosis factor-alpha , TNF-α) and lymphotoxin-alpha (LT-α3, aka, lymphotoxin or TNF-β). This receptor is referred to as the p55 or Type I Tumor Necrosis Factor Receptor (TNFRI) or CD120a. TNFRI are expressed by a variety of cell lines, tumor cells, and normal cell types including T cells, monocytes, macrophages, neutrophils, endothelial cells, hepatocytes, chondrocytes, and fibroblasts. Naive B cells express very low or undetectable levels of TNFRI whereas mature erythrocytes and platelets are uniformly negative for TNFRI expression. For the generation of the MABTNFRI-B1 hybridoma, BALB/c mice were immunized with purified, full-length human TNFRI protein. MABTNFRI-A1 specifically binds to natural and recombinant truncated forms of TNFRI.

BD Pharmingen™ Purified Mouse Anti-Human CD120a - Purified - Clone MABTNFR1-A1 - Isotype Mouse IgG1, κ - Reactivity Hu - 0.5 mg

Aufreinigung: The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.

Klon: MABTNFR1

Isotyp: IgG1 kappa

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 0.5 mg/mL

Buffer: Aqueous buffered solution containing ≤0.09 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C

Informationen zur Lagerung: Store undiluted at 4°C.

Referenzen für anti-TNFRSF1A Antikörper (ABIN2688922)

Aggarwal, Gollapudi, Gupta: "Increased TNF-alpha-induced apoptosis in lymphocytes from aged humans: changes in TNF-alpha receptor expression and activation of caspases." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 162, Issue 4, pp. 2154-61, (1999) (PubMed).

Browning, Dougas, Ngam-ek, Bourdon, Ehrenfels, Miatkowski, Zafari, Yampaglia, Lawton, Meier: "Characterization of surface lymphotoxin forms. Use of specific monoclonal antibodies and soluble receptors." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 154, Issue 1, pp. 33-46, (1995) (PubMed).

Gehr, Gentz, Brockhaus, Loetscher, Lesslauer: "Both tumor necrosis factor receptor types mediate proliferative signals in human mononuclear cell activation." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 149, Issue 3, pp. 911-7, (1992) (PubMed).

Wallach, Engelmann, Nophar, Aderka, Kemper, Hornik, Holtmann, Brakebusch: "Soluble and cell surface receptors for tumor necrosis factor." in: Agents and actions. Supplements, Vol. 35, pp. 51-7, (1992) (PubMed).

Erikstein, Smeland, Blomhoff, Funderud, Prydz, Lesslauer, Espevik: "Independent regulation of 55-kDa and 75-kDa tumor necrosis factor receptors during activation of human peripheral blood B lymphocytes." in: European journal of immunology, Vol. 21, Issue 4, pp. 1033-7, (1991) (PubMed).

Heilig, Mapara, Brockhaus, Krauth, Dörken: "Two types of TNF receptors are expressed on human normal and malignant B lymphocytes." in: Clinical immunology and immunopathology, Vol. 61, Issue 2 Pt 1, pp. 260-7, (1991) (PubMed).

Brockhaus, Schoenfeld, Schlaeger, Hunziker, Lesslauer, Loetscher: "Identification of two types of tumor necrosis factor receptors on human cell lines by monoclonal antibodies." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 87, Issue 8, pp. 3127-31, (1990) (PubMed).

Hohmann, Remy, Brockhaus, van Loon: "Two different cell types have different major receptors for human tumor necrosis factor (TNF alpha)." in: The Journal of biological chemistry, Vol. 264, Issue 25, pp. 14927-34, (1989) (PubMed).

Details zu TNFRSF1A

Target: TNFRSF1A (Tumor Necrosis Factor Receptor Superfamily, Member 1A (TNFRSF1A))

Andere Bezeichnung: CD120a (TNFRSF1A Produkte)

Synonyme: CD120a antikoerper, FPF antikoerper, MS5 antikoerper, TBP1 antikoerper, TNF-R antikoerper, TNF-R-I antikoerper, TNF-R55 antikoerper, TNFAR antikoerper, TNFR1 antikoerper, TNFR1-d2 antikoerper, TNFR55 antikoerper, TNFR60 antikoerper, p55 antikoerper, p55-R antikoerper, p60 antikoerper, TNF-R1 antikoerper, TNF-alphaR1 antikoerper, TNFRI antikoerper, TNFRp55 antikoerper, TNFalpha-R1 antikoerper, Tnfr-2 antikoerper, Tnfr1 antikoerper, fpf antikoerper, tbp1 antikoerper, p55-r antikoerper, tnf-r antikoerper, tnfar antikoerper, tnfr1 antikoerper, cd120a antikoerper, tnfr55 antikoerper, tnfr60 antikoerper, xtnfr1 antikoerper, wu:fj65b10 antikoerper, zgc:85914 antikoerper, TNFR I antikoerper, TNFRSF1A antikoerper, TNFA antikoerper, cTNF antikoerper, TNF receptor superfamily member 1A antikoerper, tumor necrosis factor receptor superfamily, member 1a antikoerper, TNF receptor superfamily member 1A S homeolog antikoerper, tumor necrosis factor antikoerper, TNFRSF1A antikoerper, Tnfrsf1a antikoerper, tnfrsf1a.S antikoerper, tnfrsf1a antikoerper, TNF antikoerper

Hintergrund: Synonyms: TNF Receptor Type I

Pathways: NF-kappaB Signalweg, Apoptose, Caspase Kaskade in der Apoptose, Hepatitis C, Ubiquitin Proteasome Pathway