Crystallin, alpha A (CRYAA) Antikörper

Antigen: Crystallin, alpha A (CRYAA)

Synonyme: CRYA1, HSPB4, Crya1, lop18, Acry-1, Crya-1, DAcry-1, AI323437, cryaa-A, CRYAA, fc06h04, MGC92036, zgc:92036, wu:fc06h04, alpha-a-crystallin

Klonalität: Polyklonal

Wirt: Kaninchen

Reaktivität: Ratte (Rattus)

Applikation: Immunhistochemie (Paraffinschnitte) (IHC (p)), Western Blot (WB)

Produktnummer: ABIN267342

Produktbeschreibung

Weitere Bezeichnung: Alpha-crystallin A chain

Gen-ID: 1409, 24273

Immunogen: Purified alpha-A crystallin from bovine lens.

Isotyp: IgG  (Passende Sekundärantikörper)

Beschreibung: Lens proteins consist almost entirely of crystallins (about 95%). Crystallins are alsofound vertebrate skeletal muscle tissue. In the lens, their structural function is to assistin maintaining the proper refractive index of the lens. The mammalian lens contains 3major classes of crystallins: alpha, beta, and gamma. Alpha-crystallin is the largest ofthe crystallins and is composed of 2 primary gene products--alpha-A and alpha-B. Thereare at least 5 different proteins comprising the beta-crystallins. The gamma-crystallinsare monomeric, but there are at least 5 gamma crystallins identified in bovine and ratlens. Alpha-Crystallin comprises 40% of total lens protein composition. In addition tomaintaining proper refractive index, it also functions in a chaperone like manner bypreventing the formation of aggregates possibly leading to cataract formation. It isbelieved that the phosphorylated states of the alpha-crystallin occur in response tocellular stress and may serve a structural control function and play a role in proteinmaintenance. Alpha-B crystallin has been linked to Alexander's disease where itaccumulates in brain cells of those afflicted. Alternate Names: anti-Heat shock protein beta 4 antibody, anti-Acry-1 antibody, anti-CRYA 1 antibody,anti-CRYA1 antibody, anti-CRYAA antibody, anti-Crystallin Alpha 1 antibody,anti-HSPB4 antibody, anti-Zonular Central Nuclear Cataract antibody.

Spezifität: This antibody does not detect the unphosphorylated form of the protein. Species Reactivity: Cross-reacts with Cow and Rat.Not yet tested in other species. Localization: Cytoplasmic.

Anwendungen

Applikationshinweise: Suggested working dilutions: Western Blot 0.1 ug/ml,Immunohistochemistry-Paraffin 10 ug/ml

Buffer: PBS. Preservative: 0.05% Sodium Azide, 30mg/ml BSA.

Lagerung: -20 Degrees Celsius, Avoid Freeze/Thaw Cycles

Forschungsgebiet: Neurologie, Enzyme

Beschränkungen: Nur für Forschungszwecke einsetzbar