DNMT3B Antikörper (DNA (Cytosine-5-)-Methyltransferase 3 beta)

Details for Product anti-DNMT3B Antibody No. ABIN2668954, Anbieter: Anmelden zum Anzeigen
Antigen
  • cb633
  • dnmt3b
  • DNMT3B
  • LOC100218113
  • ICF
  • ICF1
  • M.HsaIIIB
  • cb91
  • dnmt3bl
  • dnmt7
  • sb:cb91
  • wu:fb16h07
  • MmuIIIB
  • DNA (cytosine-5-)-methyltransferase 3 beta, duplicate b.1
  • DNA methyltransferase 3 beta
  • microtubule associated protein RP/EB family member 1
  • DNA (cytosine-5-)-methyltransferase 3 beta, duplicate a
  • DNA methyltransferase 3B
  • dnmt3bb.1
  • DNMT3B
  • MAPRE1
  • dnmt3b
  • dnmt3ba
  • Dnmt3b
Reaktivität
Human, Maus
124
62
27
4
2
2
2
2
2
2
2
1
1
1
Wirt
Maus
89
37
2
2
2
Klonalität (Klon)
Monoklonal ()
Konjugat
Dieser DNMT3B Antikörper ist unkonjugiert
4
4
4
3
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Applikation
Chromatin Immunoprecipitation (ChIP), Western Blotting (WB)
112
48
41
39
34
34
24
16
15
13
9
3
3
3
2
2
2
2
1
Optionen
Hersteller
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Hersteller Produkt- Nr.
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Immunogen This DNMT3B antibody was raised against a full-length protein corresponding to mouse DNMT3B.
Klon 52A1018
Isotyp IgG
Reinigung Affinity Purified
Andere Bezeichnung DNMT3B (DNMT3B Antibody Abstract)
Hintergrund DNMT3B - DNA methyltransferase (or DNMT 3B) proteins are involved in DNA methylation in which a methyl group is added to a cytosine residue on DNA, commonly at the C5 position of a CpG dinucleotide. Three families of DNMTs have been identified: DNMT1, DNMT2, and DNMT3. The DNMT3 family contains two active methyltransferases, DNMT3A & DNMT3B, and one DNMT3-Like protein (DNMT3L). DNMT3B has been shown to be important in the regulation of specific patterns of DNA methylation, specifically de novo methylation. Methylation of mammalian DNA has long been recognized to play a major role in a number of cellular functions such as embryonic development, genetic imprinting, X chromosome inactivation and the control of gene expression. DNA methylation is generally associated with transcriptional repression. Mutations in the DNMT3B gene cause the immunodeficiency-centromeric instability-facial anomalies (ICF) syndrome.
Molekulargewicht 96 kDa
Gen-ID 1789
Applikationshinweise Optimal working dilution should be determined by the investigator.
Beschränkungen Nur für Forschungszwecke einsetzbar
Konzentration 0.5 μg/μL
Konservierungsmittel Sodium azide
Vorsichtsmaßnahmen This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handhabung

Avoid repeated freeze/thaw cycles and keep on ice when not in storage.

Lagerung -80 °C
Informationen zur Lagerung Antibodies in solution can be stored at -80 °C for 2 years.
Haltbarkeit 6 months
Bilder des Herstellers
Western Blotting (WB) image for anti-DNA (Cytosine-5-)-Methyltransferase 3 beta (DNMT3B) antibody (ABIN2668954) DNMT3B mAb tested by Western blot. Detection of DNMT3B by Western blot. The analysis ...
Produkt verwendet in: Castro, Breiling, Luetkenhaus, Ceteci, Hausmann, Kress, Lyko, Rudel, Rapp: "MYC-induced epigenetic activation of GATA4 in lung adenocarcinoma." in: Molecular cancer research : MCR, Vol. 11, Issue 2, pp. 161-72, 2013 (PubMed).

Karius, Schnekenburger, Ghelfi, Walter, Dicato, Diederich: "Reversible epigenetic fingerprint-mediated glutathione-S-transferase P1 gene silencing in human leukemia cell lines." in: Biochemical pharmacology, Vol. 81, Issue 11, pp. 1329-42, 2011 (PubMed).

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