PARP1 Antikörper (Poly (ADP-Ribose) Polymerase 1) (N-Term)

Details for Product anti-PARP1 Antibody No. ABIN2668274, Anbieter: Anmelden zum Anzeigen
Antigen
  • BEST:LD21673
  • CG17685
  • CG17696
  • CG17718
  • CG40411
  • D.PARP
  • Dm.pARTa
  • Dmel\\CG40411
  • LD21673.3prime
  • PARP
  • PARP-1
  • PARP1
  • dPARP
  • parp
  • ADPRT
  • ADPRT 1
  • ADPRT1
  • ARTD1
  • PPOL
  • pADPRT-1
  • Adprt
  • Parp-1
  • adprt1
  • padprt-1
  • ppol
  • 5830444G22Rik
  • AI893648
  • Adprp
  • Adprt1
  • C80510
  • parp-1
  • sPARP-1
  • Poly-(ADP-ribose) polymerase
  • poly (ADP-ribose) polymerase 1
  • poly (ADP-ribose) polymerase family, member 1
  • poly ADP-ribose polymerase
  • Parp
  • PARP1
  • Parp1
  • parp1
Epitop
N-Term
57
19
19
19
19
19
19
19
18
18
18
17
15
14
12
9
8
8
8
6
5
5
4
3
3
2
2
2
2
2
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Reaktivität
Human
385
84
80
18
17
13
9
9
7
6
5
3
2
2
1
1
1
1
1
Wirt
Kaninchen
377
46
1
Klonalität
Polyklonal
Konjugat
Dieser PARP1 Antikörper ist unkonjugiert
25
24
24
24
24
23
Applikation
Chromatin Immunoprecipitation (ChIP), Western Blotting (WB)
237
231
164
50
44
41
31
22
13
12
6
4
4
3
2
1
1
1
Optionen
Hersteller
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Hersteller Produkt- Nr.
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Immunogen This PARP-1 N-terminal antibody was raised against a His-tagged fusion protein corresponding to the N-terminal half of human PARP-1 was used to generate this PARP-1 antibody.
Reinigung None
Andere Bezeichnung PARP-1 (PARP1 Antibody Abstract)
Hintergrund PARP-1 N-terminal (ADPRT) encodes a chromatin-associated enzyme, poly(ADP-ribosyl)transferase, that modifies various nuclear proteins by poly(ADP-ribosyl)ation. The modification is dependent on DNA and is involved in the regulation of various important cellular processes such as differentiation, proliferation and tumor transformation. It also plays a role in the regulation of the molecular events involved in the recovery of cells from DNA damage. Cleavage of PARP-1 (ADPRT) occurs following caspase activation during apoptosis. For additional information on PARP-1, please see the review article PARP-1: An Abundant and Ubiquitous Protein with Roles in Many Cellular Processes in the Targets & Applications section or our website.
Molekulargewicht 120 kDa
Gen-ID 142
Forschungsgebiet Enzymes
Pathways Apoptose, Caspase Kaskade in der Apoptose, DNA Reparatur, Production of Molecular Mediator of Immune Response, Maintenance of Protein Location
Applikationshinweise Optimal working dilution should be determined by the investigator.
Beschränkungen Nur für Forschungszwecke einsetzbar
Format Liquid
Konservierungsmittel Sodium azide
Vorsichtsmaßnahmen This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handhabung

Avoid repeated freeze/thaw cycles and keep on ice when not in storage.

Lagerung -20 °C
Informationen zur Lagerung Antibodies in solution can be stored at -20 °C for 2 years.
Haltbarkeit 6 months
Bilder des Herstellers
Chromatin Immunoprecipitation (ChIP) image for anti-Poly (ADP-Ribose) Polymerase 1 (PARP1) (N-Term) antibody (ABIN2668274) PARP-1 N-terminal antibody tested by ChIP analysis. Chromatin IP performed with chrom...
Western Blotting (WB) image for anti-Poly (ADP-Ribose) Polymerase 1 (PARP1) (N-Term) antibody (ABIN2668274) PARP-1 N-terminal antibody tested by Western blot. HeLa cell nuclear extract (20 µg p...
Produkt verwendet in: Myers, Peddada, Chatterjee, Friedrich, Tomoda, Krings, Thomas, Maynard, Broeker, Thomson, Pollard, Yamanaka, Burlingame, Panning: "SOX2 O-GlcNAcylation alters its protein-protein interactions and genomic occupancy to modulate gene expression in pluripotent cells." in: eLife, Vol. 5, pp. e10647, 2016 (PubMed).

Watanabe, Papoutsoglou, Maturi, Tsubakihara, Hottiger, Heldin, Moustakas: "Regulation of Bone Morphogenetic Protein Signaling by ADP-ribosylation." in: The Journal of biological chemistry, Vol. 291, Issue 24, pp. 12706-23, 2016 (PubMed).

Matveeva, Maiorano, Zhang, Eteleeb, Convertini, Chen, Infantino, Stamm, Wang, Rouchka, Fondufe-Mittendorf: "Involvement of PARP1 in the regulation of alternative splicing." in: Cell discovery, Vol. 2, pp. 15046, 2016 (PubMed).

Krishnakumar, Gamble, Frizzell, Berrocal, Kininis, Kraus: "Reciprocal binding of PARP-1 and histone H1 at promoters specifies transcriptional outcomes." in: Science (New York, N.Y.), Vol. 319, Issue 5864, pp. 819-21, 2008 (PubMed).

Kim, Mauro, Gévry, Lis, Kraus: "NAD+-dependent modulation of chromatin structure and transcription by nucleosome binding properties of PARP-1." in: Cell, Vol. 119, Issue 6, pp. 803-14, 2004 (PubMed).

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