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EZH2 Antikörper (AA 1-370)

EZH2 Reaktivität: Human, Maus IP, ChIP, ChIP-seq Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN2668200
  • Target Alle EZH2 Antikörper anzeigen
    EZH2 (Enhancer of Zeste Homolog 2 (EZH2))
    Bindungsspezifität
    • 16
    • 15
    • 15
    • 7
    • 7
    • 7
    • 4
    • 4
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 1-370
    Reaktivität
    • 134
    • 67
    • 34
    • 8
    • 6
    • 4
    • 4
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    Human, Maus
    Wirt
    • 107
    • 28
    • 1
    Kaninchen
    Klonalität
    • 99
    • 37
    Polyklonal
    Konjugat
    • 67
    • 10
    • 6
    • 6
    • 6
    • 6
    • 6
    • 6
    • 5
    • 5
    • 4
    • 4
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser EZH2 Antikörper ist unkonjugiert
    Applikation
    • 75
    • 40
    • 36
    • 28
    • 23
    • 18
    • 14
    • 13
    • 12
    • 10
    • 8
    • 3
    • 3
    • 2
    • 2
    Immunoprecipitation (IP), Chromatin Immunoprecipitation (ChIP), ChIP DNA-Sequencing (ChIP-seq)
    Aufreinigung
    None
    Immunogen
    This EZH2 antibody was raised against a recombinant fusion protein corresponding to amino acids 1-370 of mouse EZH2.
    Top Product
    Discover our top product EZH2 Primärantikörper
  • Applikationshinweise
    Optimal working dilution should be determined by the investigator.
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handhabung

    Avoid repeated freeze/thaw cycles and keep on ice when not in storage.

    Lagerung
    -20 °C
    Informationen zur Lagerung
    Antibodies in solution can be stored at -20 °C for 2 years.
    Haltbarkeit
    6 months
  • LaFave, Béguelin, Koche, Teater, Spitzer, Chramiec, Papalexi, Keller, Hricik, Konstantinoff, Micol, Durham, Knutson, Campbell, Blum, Shi, Doud, Krivtsov, Chung, Khodos, de Stanchina, Ouerfelli et al.: "Loss of BAP1 function leads to EZH2-dependent transformation. ..." in: Nature medicine, Vol. 21, Issue 11, pp. 1344-9, (2015) (PubMed).

    Knutson, Kawano, Minoshima, Warholic, Huang, Xiao, Kadowaki, Uesugi, Kuznetsov, Kumar, Wigle, Klaus, Allain, Raimondi, Waters, Smith, Porter-Scott, Chesworth, Moyer, Copeland, Richon, Uenaka, Pollock et al.: "Selective inhibition of EZH2 by EPZ-6438 leads to potent antitumor activity in EZH2-mutant non-Hodgkin lymphoma. ..." in: Molecular cancer therapeutics, Vol. 13, Issue 4, pp. 842-54, (2014) (PubMed).

    Inoue, Kitaura, Togami, Nishimura, Enomoto, Uchida, Kagiyama, Kawabata, Nakahara, Izawa, Oki, Maehara, Isobe, Tsuchiya, Harada, Harada, Ochiya, Aburatani, Kimura, Thol, Heuser, Levine, Abdel-Wahab et al.: "Myelodysplastic syndromes are induced by histone methylation–altering ASXL1 mutations. ..." in: The Journal of clinical investigation, Vol. 123, Issue 11, pp. 4627-40, (2014) (PubMed).

    Kumar, Duester: "Retinoic acid controls body axis extension by directly repressing Fgf8 transcription." in: Development (Cambridge, England), Vol. 141, Issue 15, pp. 2972-7, (2014) (PubMed).

    Tong, He, Xie, Mochizuki, Liu, Mochizuki, Meng, Sun, Zhang, Guo, Hexner, Zhang: "Ezh2 regulates transcriptional and posttranslational expression of T-bet and promotes Th1 cell responses mediating aplastic anemia in mice." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 192, Issue 11, pp. 5012-22, (2014) (PubMed).

    Bender, Tang, Lindroth, Hovestadt, Jones, Kool, Zapatka, Northcott, Sturm, Wang, Radlwimmer, Højfeldt, Truffaux, Castel, Schubert, Ryzhova, Seker-Cin, Gronych, Johann, Stark, Meyer, Milde, Schuhmann et al.: "Reduced H3K27me3 and DNA hypomethylation are major drivers of gene expression in K27M mutant pediatric high-grade gliomas. ..." in: Cancer cell, Vol. 24, Issue 5, pp. 660-72, (2013) (PubMed).

    Chng, Chang, Tan, Yang, Hong, Sng, Cheung: "A transcriptional repressor co-regulatory network governing androgen response in prostate cancers." in: The EMBO journal, Vol. 31, Issue 12, pp. 2810-23, (2012) (PubMed).

    Abdel-Wahab, Adli, LaFave, Gao, Hricik, Shih, Pandey, Patel, Chung, Koche, Perna, Zhao, Taylor, Park, Carroll, Melnick, Nimer, Jaffe, Aifantis, Bernstein, Levine: "ASXL1 mutations promote myeloid transformation through loss of PRC2-mediated gene repression." in: Cancer cell, Vol. 22, Issue 2, pp. 180-93, (2012) (PubMed).

    Bredfeldt, Greathouse, Safe, Hung, Bedford, Walker: "Xenoestrogen-induced regulation of EZH2 and histone methylation via estrogen receptor signaling to PI3K/AKT." in: Molecular endocrinology (Baltimore, Md.), Vol. 24, Issue 5, pp. 993-1006, (2010) (PubMed).

  • Target
    EZH2 (Enhancer of Zeste Homolog 2 (EZH2))
    Andere Bezeichnung
    EZH2 (EZH2 Produkte)
    Synonyme
    ENX-1 antikoerper, ENX1 antikoerper, EZH1 antikoerper, EZH2b antikoerper, KMT6 antikoerper, KMT6A antikoerper, WVS antikoerper, WVS2 antikoerper, eya2 antikoerper, im:7149338 antikoerper, zgc:136376 antikoerper, zgc:152758 antikoerper, EZH2 antikoerper, enx-1 antikoerper, enx1 antikoerper, ezh1 antikoerper, kmt6 antikoerper, xez antikoerper, Enx-1 antikoerper, Enx1h antikoerper, mKIAA4065 antikoerper, ezh2 antikoerper, olezh2 antikoerper, enhancer of zeste 2 polycomb repressive complex 2 subunit antikoerper, enhancer of zeste 2 polycomb repressive complex 2 subunit L homeolog antikoerper, enhancer of zeste 2 polycomb repressive complex 2 subunit S homeolog antikoerper, EZH2 antikoerper, ezh2 antikoerper, Ezh2 antikoerper, ezh2.L antikoerper, ezh2.S antikoerper
    Molekulargewicht
    96 kDa
    Gen-ID
    2146
    Pathways
    Retinoic Acid Receptor Signaling Pathway, Regulation of Muscle Cell Differentiation
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